gene 1,242 words KG: IL6R
Contents

IL6R Gene

🧬 Gene Info
Gene SymbolIL6R
Full NameInterleukin 6 Receptor
Chromosome1q21.3
Protein TypeReceptor
FunctionIL-6R is a type I cytokine receptor that exists in both membrane-bound and soluble forms, mediating IL-6 signaling through multiple pathways:
Molecular Weight50 kDa
Amino Acids468 aa
Exons10
PathwaysMAPK, PI3K
UniProt IDP08887
NCBI Gene ID3570
Ensembl IDENSG00000160712
OMIM147610
GeneCardsIL6R
Human Protein AtlasIL6R
Associated Diseasesbacterial_infections, Cancer, Carcinoma, Cardiovascular, Hepatitis, Pneumonia
InteractionsAND, CANCER, DNA, GENES, gp130, HNF4A
KG Connections147 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

APOE-Dependent Autophagy Restoration
Score: 0.88
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

Related Analyses (2)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (11)

Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.51
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40
Biomarker-Guided Sequential Therapy Selection in Alzheimer's
clinical · proposed · Score: 0.40
tACS Connectivity Trial in Early Alzheimer's
clinical · proposed · Score: 0.40

See Also (10)

IL6 (Redirect)
redirect · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
Genes
index · KG edge: activates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

IL6R associated_with bacterial_infections
IL6 interacts_with IL6R
IL6R activates gp130
proteases catalyzes IL6R
IL6 associated_with IL6R
IL6R associated_with IL6
IL6 activates IL6R
HNF4A activates IL6R
IL6R activates STAT3
PDGFRA activates IL6R

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