gene 1,594 words KG: IFNAR1
Contents

IFNAR1 — Interferon Alpha Receptor 1

🧬 Gene Info
Gene SymbolIFNAR1
Full NameInterferon Alpha Receptor 1
AliasesGene page for IFNAR1
Chromosome21q22.11
Primary ExpressionUbiquitous (immune cells, neurons, astrocytes, microglia)
Amino Acids557 aa
Exons22
PathwaysCgas-Sting, Complement, Immune Response, Jak-Stat, Microglia Activation
UniProt IDP17181
NCBI Gene ID3454
Ensembl IDENSG00000142149
OMIM146590
GeneCardsIFNAR1
Human Protein AtlasIFNAR1
IFNAR1Ligand-binding chain with lower affinity
Associated Diseasesneurodegeneration
InteractionsAND, APOE, ASTROCYTES, C4B, CGAS, CGAS-STING
KG Connections92 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: activates

Knowledge Graph (12 edges)

STING activates IFNAR1
CGAS activates IFNAR1
IFNAR1 activates CGAS
IRF7 activates IFNAR1
STING1 inhibits IFNAR1
IFNAR1 inhibits STING
IFNAR1 activates APOE
IFNAR1 activates STING
IFNAR1 activates C4B
C4B activates IFNAR1

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