concept

KYNURENINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KYNURENINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

24Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	KYNURENINE
Key Genes/Proteins	CXCL10, HUNTINGTIN
Related Diseases	CYTOKINES, HUNTINGTON'S DISEASE, INFLAMMATION, LIPID PEROXIDATION, NEURODEGENERATION
Related Pathways	KYNURENINE PATHWAY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kynurenine Pathway Dysregulation in 4R-Tauopathies

mechanism · 3467 words

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Pathway Diagram

graph TD
    KYNURENINE[KYNURENINE]
    KYNURENINE -->|inhibits| Ferroptosis[Ferroptosis]
    KYNURENINE -->|interacts| HUNTINGTIN[HUNTINGTIN]
    KYNURENINE -->|inhibits| CXCL10[CXCL10]
    KYNURENINE -->|interacts| NEURODEGENERATION[NEURODEGENERATION]
    KYNURENINE -->|produces| CYTOKINES[CYTOKINES]
    KYNURENINE -->|activates| OXIDATIVE_STRESS[OXIDATIVE STRESS]
    KYNURENINE -->|interacts| INFLAMMATION[INFLAMMATION]
    KYNURENINE -->|activates| MICROGLIA[MICROGLIA]
    kynurenine_aminotransferases[kynurenine aminotransferases] -->|regulates| KYNURENINE
    IDO1[IDO1] -->|produces| KYNURENINE

Outgoing (24)

Target	Relation	Type	Str
ferroptosis	inhibits	phenotype	0.85
Ferroptosis	inhibits	process	0.85
NICOTINAMIDE	activates	drug	0.65
ASTROCYTE	treats	cell_type	0.65
LIPID PEROXIDATION	causes	phenotype	0.65
HUNTINGTIN	interacts_with	protein	0.65
CXCL10	inhibits	gene	0.65
CXCL10	activates	gene	0.65
NEURODEGENERATION	interacts_with	disease	0.65
CYTOKINES	produces	phenotype	0.65
CYTOKINES	activates	phenotype	0.65
INFLAMMATION	interacts_with	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
CYTOKINES	regulates	phenotype	0.65
NEURODEGENERATION	activates	disease	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
SLC7A11	interacts_with	gene	0.64
NAD_metabolism	participates_in	pathway	0.64
cell_survival	activates	phenotype	0.64
NEURODEGENERATION	expressed_in	disease	0.55
CYTOKINES	implicated_in	phenotype	0.55
HUNTINGTON'S DISEASE	associated_with	disease	0.45
TNF	associated_with	gene	0.45
MELATONIN	associated_with	drug	0.45

Incoming (7)

Source	Relation	Type	Str
kynurenine aminotransferases	regulates	protein	0.90
SLC7A11	associated_with	gene	0.85
IDO1	produces	protein	0.72
KYNURENINE PATHWAY	associated_with	pathway	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
NICOTINAMIDE	associated_with	drug	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KYNURENINE in their description or question text

No additional research found