| Gene Symbol | HSP90AA1 |
| Full Name | Heat Shock Protein 90 Alpha Family Class A Member 1 |
| Chromosome | 14q32.31 |
| Protein Type | Chaperone |
| Target Class | Chaperone |
| Function | Small molecule inhibitor binding to ATP-binding pocket of chaperone |
| Mechanism of Action | Small molecule inhibitor binding to ATP-binding pocket of chaperone |
| Druggability | Low (0.45) |
| Clinical Stage | Phase III |
| Molecular Weight | 90 kDa |
| Amino Acids | 854 aa |
| Exons | 11 |
| Pathways | NF-κB |
| UniProt ID | H0YJF5 |
| NCBI Gene ID | 3320 |
| Ensembl ID | ENSG00000100425 |
| OMIM | 140571 |
| GeneCards | HSP90AA1 |
| Human Protein Atlas | HSP90AA1 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | 17-AAG, 17-Dmag, 17-DMAG, Atbc, Bisphenol F, Chrysotoxine |
| Interactions | AHSA1, AKT, AKT1, AMYLOID, AND, ANXA2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HSP90-Tau Disaggregation Complex Enhancement HSP90-Tau Disaggregation Complex Enhancement Membrane-Localized HSP90 Disruption (+2 more) |
| KG Connections | 711 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!