Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSP90-Tau Disaggregation Complex Enhancement: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP90AA1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HSP90-Tau Disaggregation Complex Enhancement | 0.634 | neurodegeneration | Tau propagation mechanisms and therapeut |
| HSP90-Tau Disaggregation Complex Enhancement | 0.551 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| Amyloid plaque load analysis in triple-mutant mouse brains | exploratory | Alzheimer's disease | 0.880 | 0.00 | APP/PSEN1/GD3S-/- triple-trans | proposed | N/A |
| Reelin treatment rescue via ApoER2 in CD2AP mutant mice | validation | Alzheimer's disease | 0.870 | 0.00 | mice | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Endothelin-1 receptor A antagonist rescue experiment | validation | Alzheimer's disease | 0.850 | 0.00 | mice | proposed | N/A |
| In vivo BBB transport of LPS-carrying bEVs | validation | Alzheimer's disease | 0.850 | 0.00 | mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| 16S rRNA sequencing of gut microbiome in PH-PS treated mice | exploratory | Alzheimer's disease | 0.800 | 0.00 | 5×FAD transgenic mice | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gigantol: a principal bioactive constituent of Dendrobium species-multi-target m [PMID:40939944] | Shi S, Zhu C, Xu J, Sui Q, Zhu S, Zhang | Journal of ethnopharmacology | 2026 | 0 |
| Biomimetic cancer cell membrane-coated liposomal nanocarriers loaded with silibi [PMID:41585438] | Yao J, Sun Q, Zhang X, Yang D, Wu H et a | Mater Today Bio | 2026 | 0 |
| Exploring synergistic therapeutic potential of Erlotinib and artemisinin in non- [PMID:41672289] | Suleman F, Khan T, Alshehade SA, Ali M, | Clin Chim Acta | 2026 | 0 |
| Methyl-4-hydroxybenzoate induces osteoporosis via the AKT1/LC3B/Beclin1 autophag [PMID:41740552] | Fu F, Wang W, Li Y, Shi S, Huang J, Liu | Ecotoxicology and environmenta | 2026 | 0 |
| Chronic Thermal Stress During Early Zebrafish (Danio rerio) Development Induces [PMID:41793424] | Adzijovski M, Schultz AG, Oxley APA, Ber | Fish physiology and biochemist | 2026 | 0 |
| α-Glucosidase inhibitor: identifying key targets and mechanisms in type 2 diabet [PMID:41907120] | Garg SS, Vijh D, Gupta P, Gupta J, Malik | 3 Biotech | 2026 | 0 |
| Elucidating the mechanisms of aristolochic acid-induced upper tract urothelial c [PMID:41780445] | Liu T, Yao Y, Xu Y, Zhang H, Sun L, Zhan | Computational biology and chem | 2026 | 0 |
| A Study on the Mechanism of Acetyl Tributyl Citrate-Induced Infertility Toxicity [PMID:41898778] | Sun X, Chen P, Han Y, Du Y, Sun S, Miu J | International journal of molec | 2026 | 0 |
| Investigating the clinical efficacy, safety and molecular mechanism of sulforaph [PMID:41275316] | Long J, Liao X, Tang Z, Han K, Chen J, W | BMC pharmacology & toxicology | 2025 | 0 |
| Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's diseas [PMID:40116694] | Sordu P, Alaylıoğlu M, Samancı B, Bulu E | J Alzheimers Dis | 2025 | 0 |
| The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among hu [PMID:40436281] | Soriano-Herrador C, Ubeda-Banon I, Villa | Neurobiol Dis | 2025 | 0 |
| Mapping the pathogenic nexus: Gene overlap and protein interaction networks in A [PMID:40973403] | Chowdhury MR, Deepa VS, Raja VK | Adv Protein Chem Struct Biol | 2025 | 0 |
| The mechanism of probiotics in pregnancy outcomes in overweight or obese pregnan [PMID:40859213] | Zhong T, Sun J, Miao M, Sun G | BMC pregnancy and childbirth | 2025 | 0 |
| Chrysotoxine regulates ferroptosis and the PI3K/AKT/mTOR pathway to prevent cerv [PMID:39557107] | Zhou J, Guo Z, Peng X, Wu B, Meng Q, Lu | Journal of ethnopharmacology | 2025 | 0 |
| A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execut [PMID:38261660] | Iskandar K, Foo J, Liew AQX, Zhu H, Rama | Autophagy | 2024 | 0 |
| Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal [PMID:38247340] | Astillero-Lopez V, Villar-Conde S, Gonza | Brain pathology (Zurich, Switz | 2024 | 0 |
| Efficient analysis of toxicity and mechanisms of environmental pollutants with n [PMID:37858827] | Huang S | The Science of the total envir | 2023 | 0 |
| Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longe [PMID:35941759] | Yang S, Nie T, She H, Tao K, Lu F et al. | Autophagy | 2023 | 0 |
| Network pharmacology and molecular docking combined with widely targeted metabol [PMID:37150086] | Liu Y, Sun W, Shen N, Hao W, Xin H, Che | Computers in biology and medic | 2023 | 0 |
| Paeoniflorin protects against cisplatin-induced acute kidney injury through targ [PMID:36972781] | Zhang MY, Ma LJ, Jiang L, Gao L, Wang X, | Journal of ethnopharmacology | 2023 | 0 |
Multi-agent debates referencing this entity