Contents

HSP90AA1 Protein

🔬 Protein Info

Gene Symbol	HSP90AA1
Full Name	Heat Shock Protein 90 Alpha Family Class A Member 1
Chromosome	14q32.31
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule inhibitor binding to ATP-binding pocket of chaperone
Mechanism of Action	Small molecule inhibitor binding to ATP-binding pocket of chaperone
Subcellular Localization	** Cytoplasm, Nucleus
Druggability	Low (0.45)
Clinical Stage	Phase III
Molecular Weight	90 kDa
Amino Acids	854 aa
Exons	11
Pathways	NF-κB
UniProt ID	H0YJF5
NCBI Gene ID	3320
Ensembl ID	ENSG00000100425
OMIM	140571
GeneCards	HSP90AA1
Human Protein Atlas	HSP90AA1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	17-Dmag, 17-DMAG, Atbc, Bisphenol F, Chrysotoxine, Nvp-Auy922
Interactions	AHSA1, AKT, AKT1, AMYLOID, AND, ANXA2
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HSP90-Tau Disaggregation Complex Enhancement HSP90-Tau Disaggregation Complex Enhancement
KG Connections	710 knowledge graph edges
Databases	GeneCards HPA STRING

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