gene 1,802 words KG: FADD
Contents

FADD Gene

🧬 Gene Info
Gene SymbolFADD
AliasesFas-Associated via Death Domain
Chromosome11q13.3
Protein TypeAdaptor Protein
Functionis a critical adaptor protein that serves as a molecular bridge between death receptor activation and caspase-mediated apoptosis.
Molecular Weight23 kDa
Amino Acids208 aa
Pathwayssignaling: [@supsup2014], NF-κB
UniProt IDQ13131
NCBI Gene ID3558
GeneCardsFADD
Human Protein AtlasFADD
Associated Diseasestraumatic brain injury
InteractionsABCG2, Actin, AND, APOPTOSIS, BAX, BCL-2
KG Connections159 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activates
BAX Gene
gene · KG edge: activates
CASP6 — Caspase-6
gene · KG edge: interacts_with
casp8
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

BAX activates FADD
DRP1 activates FADD
FADD activates NRF2
FADD activates ABCG2
FADD activates ZBP1
FADD activates MFN2
FADD activates GSDMD
FADD activates RIPK1
FADD activates RAB7A
FADD activates CAT

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.