concept

ENTORHINAL CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENTORHINAL CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

226Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	ENTORHINAL CORTEX
Key Genes/Proteins	AKT, aldh1l1, ALZHEIMER, AMYLOID, AMYLOID-BETA, ANXA2
Related Diseases	AGING, Alzheimer'S Disease, ALZHEIMER'S DISEASE, AMYLOID PLAQUES

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Entorhinal Cortex

brain · 3091 words

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Pathway Diagram

graph TD
    ENTORHINAL_CORTEX["ENTORHINAL CORTEX"]
    ENTORHINAL_CORTEX -->|"involved_in"| Spatial_Navigation["Spatial Navigation"]
    ENTORHINAL_CORTEX -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    ENTORHINAL_CORTEX -->|"inhibits"| MICROGLIA["MICROGLIA"]
    ENTORHINAL_CORTEX -->|"inhibits"| TAU["TAU"]
    ENTORHINAL_CORTEX -->|"interacts"| WHITE_MATTER["WHITE MATTER"]
    ENTORHINAL_CORTEX -->|"expressed in"| NEURON["NEURON"]
    Neurofibrillary_Tangles["Neurofibrillary Tangles"] -->|"expressed in"| ENTORHINAL_CORTEX
    Impaired_Neuronal_Activity["Impaired Neuronal Activity"] -->|"expressed in"| ENTORHINAL_CORTEX
    Cell_Death["Cell Death"] -->|"involved_in"| ENTORHINAL_CORTEX
    VIMENTIN["VIMENTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ENTORHINAL_CORTEX
    NESTIN["NESTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    SOX2["SOX2"] -->|"expressed in"| ENTORHINAL_CORTEX
    GENES["GENES"] -->|"expressed in"| ENTORHINAL_CORTEX

Outgoing (64)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Memory Impairments	associated_with	phenotype	0.85
Spatial Navigation	involved_in	process	0.80
Mild Cognitive Impairment	involved_in	disease	0.80
tau vulnerability	associated_with	mechanism	0.70
P2RX7	inhibits	gene	0.65
AQP4	associated_with	gene	0.50
MICROGLIA	inhibits	cell_type	0.50
TAU	inhibits	protein	0.50
LRP1	associated_with	gene	0.50
PHOSPHO-TAU	associated_with	protein	0.50
NEURON	associated_with	cell_type	0.50
HIPPOCAMPUS	expressed_in	brain_region	0.50
MITOPHAGY	associated_with	phenotype	0.50
PINK1	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
EXCITOTOXICITY	associated_with	phenotype	0.50
PRION	associated_with	protein	0.50
SIRT3	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
FDG-PET	associated_with	biomarker	0.50
CSF	associated_with	phenotype	0.50
MMSE	associated_with	biomarker	0.50
GRANULE CELLS	associated_with	cell_type	0.50
CERAMIDE	associated_with	phenotype	0.50
AMYLOID PET	associated_with	biomarker	0.50
IDH2	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
PSEN1	associated_with	gene	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
CELL SURVIVAL	associated_with	phenotype	0.50
AMYLOID-BETA	associated_with	protein	0.50
P-TAU	associated_with	protein	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
FUS	associated_with	gene	0.45
IBA1	associated_with	gene	0.45
P2RX7	associated_with	gene	0.45
WNT PATHWAY	associated_with	pathway	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
NEUROGENESIS	associated_with	phenotype	0.45
JNK	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
ASTROCYTE	associated_with	cell_type	0.45
GFAP	associated_with	gene	0.45
AMYLOID PLAQUES	associated_with	phenotype	0.45
TDP-43	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
TAU	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45

Incoming (162)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Neurofibrillary Tangles	expressed_in	biomarker	0.90
Impaired Neuronal Activity	expressed_in	phenotype	0.90
AMYLOID	associated_with	protein	0.90
Cell Death	involved_in	process	0.85
LRP-1	expressed_in	gene	0.80
Alzheimer's disease	affects	disease	0.80
GFAP	expressed_in	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
HDAC3	inhibits	gene	0.70
AGING	stabilizes	phenotype	0.70
TAU	stabilizes	protein	0.70
TAU	regulates	protein	0.70
neurodegeneration	affects	disease	0.70
NEURONS	causes	cell_type	0.70
MICROGLIA	associated_with	cell_type	0.66
CA1	inhibits	brain_region	0.65
TAU	phosphorylates	protein	0.65
APP	treats	gene	0.65
CORTEX	treats	brain_region	0.65
ASTROCYTE	inhibits	cell_type	0.65
TAU	causes	protein	0.65
TAU	associated_with	protein	0.65
TAU	interacts_with	protein	0.65
neuroinflammation	affects	disease	0.60
HSP90AA1	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
NEURON	depleted_in	cell_type	0.60
HDAC	expressed_in	gene	0.60
axon	enriched_in	organelle	0.60
synaptic plasticity	active_in	pathway	0.60
FDG-PET	treats	biomarker	0.60
FDG-PET	stabilizes	biomarker	0.60
IBA1	expressed_in	gene	0.60
APP	inhibits	gene	0.58
ASTROCYTES	inhibits	cell_type	0.58
MICROGLIA	inhibits	cell_type	0.56
SST	expressed_in	gene	0.55
TAU	expressed_in	gene	0.55
NEURODEGENERATION	expressed_in	gene	0.55
HUB GENES	expressed_in	gene	0.55
DNA	expressed_in	gene	0.55
ATP	expressed_in	gene	0.55
RNA	expressed_in	gene	0.55
MITOCHONDRIA	expressed_in	gene	0.55
TAUOPATHY	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	expressed_in	gene	0.55
ALDH1L1	expressed_in	gene	0.55
EGF	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Spatially Resolved Oligodendrocyte-Astrocyte Communication Networks Disrupted in

neurodegeneration | 2026-04-27 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What spatially resolved cell-cell communication networks between oligodendrocyte

active · Rounds: 6 · Score: 0.83 · 2026-04-27

Related Research

Hypotheses and analyses mentioning ENTORHINAL CORTEX in their description or question text

No additional research found