protein 1,375 words KG: EIF4G1
Contents

EIF4G1 Protein

🔬 Protein Info
Gene SymbolEIF4G1
Chromosome3p14.2
Functionis a large scaffolding protein (approximately 175 kDa) that serves as the core component of the eIF4F translation initiation complex.
Molecular Weight220 kDa
Amino Acids1598 aa
Exons33
PathwaysNF-κB, mTOR
Ensembl IDENSG00000114867
GeneCardsEIF4G1
Human Protein AtlasEIF4G1
Associated Diseasesneurodegeneration
InteractionsATG5, ATP13A2, ATXN2, CASP1, CHMP3, DISC1
KG Connections51 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.98
APOE-Dependent Autophagy Restoration
Score: 0.88
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: expressed_in
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: interacts_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: activates

Knowledge Graph (12 edges)

CASP1 interacts_with EIF4G1
MAPK8 interacts_with EIF4G1
CD8 expressed_in EIF4G1
EIF4G1 interacts_with ATG5
ATXN2 activates EIF4G1
LRRK2 activates EIF4G1
ATP13A2 activates EIF4G1
VPS35 activates EIF4G1
NBN regulates EIF4G1
SGK3 regulates EIF4G1

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