gene 1,398 words KG: EIF4G1
Contents

EIF4G1 Gene

🧬 Gene Info
Gene SymbolEIF4G1
Chromosome3p14.2
Functionis a large scaffolding protein (approximately 175 kDa) that serves as the core component of the eIF4F translation initiation complex.
Molecular Weight220 kDa
Amino Acids1598 aa
Exons33
PathwaysNF-κB, mTOR
Ensembl IDENSG00000114867
GeneCardsEIF4G1
Human Protein AtlasEIF4G1
Associated Diseasesneurodegeneration
InteractionsATG5, ATP13A2, ATXN2, CASP1, CHMP3, DISC1
KG Connections51 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: expressed_in
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: regulates
ATG5 — Autophagy Related 5
gene · KG edge: interacts_with
ATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: activates

Knowledge Graph (12 edges)

CASP1 interacts_with EIF4G1
MAPK8 interacts_with EIF4G1
CD8 expressed_in EIF4G1
EIF4G1 interacts_with ATG5
ATXN2 activates EIF4G1
LRRK2 activates EIF4G1
ATP13A2 activates EIF4G1
VPS35 activates EIF4G1
NBN regulates EIF4G1
SGK3 regulates EIF4G1

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