biomarker 2,458 words KG: CX3CL1
Contents

Fractalkine (CX3CL1) - Neuroinflammation Biomarker

🔬 Protein Info
Gene SymbolCX3CL1
Full NameFractalkine (C-X3-C Motif Chemokine Ligand 1)
AliasesC-X3-C Motif Chemokine Ligand 1
Chromosome16q13
Primary ExpressionNeurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids373 aa
PathwaysNeuroinflammatory
UniProt IDP78423
NCBI Gene ID6376
Ensembl IDENSG00000006210
OMIM601880
GeneCardsCX3CL1
Human Protein AtlasCX3CL1
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsAGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections483 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (26)

Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
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Related Analyses (10)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (10)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - ALOX15 overexpression in healthy astrocytes should be
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · completed · Score: 0.40

Knowledge Graph (12 edges)

CX3CR1 therapeutic_target CX3CL1
CX3CL1 expressed_in OVERVIEW
CX3CL1 associated_with CXCR1
FGF21 activates CX3CL1
APP biomarker_for CX3CL1
FNDC5 activates CX3CL1
S100B biomarker_for CX3CL1
PLAU activates CX3CL1
CXCL10 activates CX3CL1
C1Q biomarker_for CX3CL1

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