gene 1,391 words KG: CX3CL1
Contents

CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

🧬 Gene Info
Gene SymbolCX3CL1
Full NameFractalkine (C-X3-C Motif Chemokine Ligand 1)
AliasesC-X3-C Motif Chemokine Ligand 1
Chromosome16q13
Primary ExpressionNeurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids373 aa
PathwaysNeuroinflammatory
UniProt IDP78423
NCBI Gene ID6376
Ensembl IDENSG00000006210
OMIM601880
GeneCardsCX3CL1
Human Protein AtlasCX3CL1
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsAGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections483 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (7)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

CX3CR1 therapeutic_target CX3CL1
CX3CL1 expressed_in OVERVIEW
CX3CL1 associated_with CXCR1
FGF21 activates CX3CL1
APP biomarker_for CX3CL1
FNDC5 activates CX3CL1
S100B biomarker_for CX3CL1
PLAU activates CX3CL1
CXCL10 activates CX3CL1
C1Q biomarker_for CX3CL1

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