disease

Gastric Cancer

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Gastric Cancer: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

491Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Disease Info

Associated Genes	ACVR2A, AKT, APOPTOSIS, ARID1A, ATP2A3, AURKA, BAD, BAX
Therapeutic Agents	Curcumin, Ginger, Nobiletin, Zolbetuximab
KG Connections	473 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    Gastric_Cancer["Gastric Cancer"]
    Apoptosis["Apoptosis"]
    Gastric_Cancer -->|"activates"| Apoptosis
    Drug_Resistance["Drug Resistance"]
    Gastric_Cancer -->|"therapeutic_target"| Drug_Resistance
    Metastasis["Metastasis"]
    Gastric_Cancer -->|"regulates"| Metastasis
    Immunotherapy["Immunotherapy"]
    Gastric_Cancer -->|"therapeutic_target"| Immunotherapy
    Epigenetic["Epigenetic"]
    Gastric_Cancer -->|"associated_with"| Epigenetic
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| Gastric_Cancer
    Cancer{"Cancer"}
    Cancer -->|"therapeutic_target"| Gastric_Cancer
    Als{"Als"}
    Als -->|"therapeutic_target"| Gastric_Cancer
    style Gastric_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (123)

Target	Relation	Type	Str
Apoptosis	activates	pathway	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Peritoneal Metastasis	associated_with	phenotype	0.90
Metastasis	regulates	pathway	0.90
Digestive System Cancers	associated_with	disease	0.80
Invasion	activates	pathway	0.80
Immunotherapy	therapeutic_target	pathway	0.80
Epigenetic	therapeutic_target	pathway	0.80
Epigenetic	associated_with	pathway	0.80
Metastasis	activates	pathway	0.80
Microrna	associated_with	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
Invasion	expressed_in	pathway	0.70
Tumor Microenvironment	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Ferroptosis	activates	pathway	0.70
Apoptosis	treats	pathway	0.70
Mismatch Repair	associated_with	pathway	0.70
Wnt	therapeutic_target	pathway	0.70
Angiogenesis	regulates	pathway	0.70
Microrna	regulates	pathway	0.70
Pi3K/Akt	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Metastasis	interacts_with	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Invasion	interacts_with	pathway	0.60
Cell Cycle	activates	pathway	0.60
Er Stress	activates	pathway	0.60
Erk Signaling	inhibits	pathway	0.60
Egfr Signaling	therapeutic_target	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Immune Checkpoint	treats	pathway	0.60
Mtor	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Lipid Metabolism	inhibits	pathway	0.60
Invasion	implicated_in	pathway	0.60
Checkpoint Inhibitor	treats	pathway	0.60
Metastasis	therapeutic_target	pathway	0.60
Differentiation	therapeutic_target	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
Dna Methylation	regulates	pathway	0.60
Histone Modification	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Mismatch Repair	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Erk Signaling	causes	pathway	0.60

Incoming (368)

Source	Relation	Type	Str
CANCER	inhibits	gene	1.00
Cancer	inhibits	disease	1.00
Cancer	activates	disease	1.00
CANCER	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	associated_with	disease	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
ERBB2	associated_with	gene	0.98
HER2	associated_with	protein	0.98
CLDN18	biomarker_for	protein	0.95
Zolbetuximab	treats	drug	0.95
PI3K/AKT/mTOR	associated_with	pathway	0.95
Chronic Atrophic Gastritis	risk_factor_for	disease	0.95
Peritoneal Metastasis	associated_with	phenotype	0.95
CANCER	expressed_in	gene	0.95
HER2 overexpression	risk_factor_for	phenotype	0.95
Tumor	associated_with	disease	0.95
Colorectal Cancer	associated_with	disease	0.95
MAPK	associated_with	pathway	0.95
Als	associated_with	disease	0.95
OVERVIEW	therapeutic_target	gene	0.95
CANCER	regulates	gene	0.95
Tumor	activates	disease	0.95
Tumor	inhibits	disease	0.95
Claudin 18.2	biomarker_for	protein	0.95
Streptococcus anginosus	risk_factor_for	compound	0.95
Curcumin	treats	compound	0.95
CLDN18.2	biomarker_for	protein	0.95
Nobiletin	treats	compound	0.93
AURKA	associated_with	gene	0.92
NF-κB	promotes	pathway	0.90
gastric intestinal metaplasia	risk_factor_for	phenotype	0.90
PRMT1	associated_with	gene	0.90
ATP2A3	associated_with	gene	0.90
PIEZO1	therapeutic_target	gene	0.90
Ferroptosis	associated_with	process	0.88
Caf	contributes_to	cell_type	0.85
SERCA3	biomarker_for	protein	0.85
Hypoxia	associated_with	process	0.85
PRMT1/BTG2 Axis	involved_in	pathway	0.85
Cancer	expressed_in	disease	0.85
Ginger	treats	drug	0.85
DNA	therapeutic_target	gene	0.85
EGFR	therapeutic_target	gene	0.85
MAPK inhibitors	treats	drug	0.85
MCOLN1	targets	protein	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Gastric Cancer in their description or question text

No additional research found