protein 675 words KG: CD2APPROTEIN
Contents

CD2AP Protein

🔬 Protein Info
Gene SymbolCD2AP
Full NameCD2-Associated Protein
Chromosome6p12.3
Protein FamilySH3 domain-containing adaptor proteins
Functionis a scaffolding protein that plays critical roles in immune cell signaling, cytoskeletal organization, and receptor trafficking.
Primary Expressionthe brain, pa
Molecular Weight70 kDa
Amino Acids639 aa
Exons13
Gene TypeProtein coding
PathwaysEndocytosis
UniProt IDQ9Y5K7
NCBI Gene ID9501
Ensembl IDENSG00000198034
OMIM604332
GeneCardsCD2AP
Human Protein AtlasCD2AP
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
InteractionsABCA1, ABCA7, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE
KG Connections484 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (10)

Endothelial CD2AP knockdown effects on memory in male mice
validation · proposed · Score: 0.90
CD2AP downregulation in brain endothelial cells - memory fun
validation · proposed · Score: 0.90
Reelin glycoprotein treatment rescue experiment
validation · proposed · Score: 0.90
Cerebrovascular function analysis in CD2AP mutant mice
validation · proposed · Score: 0.90
Cerebral blood flow regulation in CD2AP mutant mice
validation · proposed · Score: 0.88

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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