Contents

CD2AP Synaptic Dysfunction Alzheimer's Disease Causal Chain

🔬 Protein Info

Gene Symbol	ent-gene-c2a13a11
Proline-rich region	binds SH3 domain-containing proteins
N-terminal dimerization domain	allows formation of multiprotein complexes
Reduced surface expression	CD2AP knockdown reduces NMDA receptor surface levels by 30-40%
Impaired signaling	Decreased phosphorylation of NR2B subunits and downstream MAPK/ERK signaling
Synaptic plasticity deficits	Long-term potentiation (LTP) is significantly impaired in CD2AP haploinsufficient neurons
Databases	GeneCards UniProt NCBI Gene HPA STRING

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