| Gene Symbol | ent-gene-5fac1535 |
| Function | - Presynaptic modulation - Alters neurotransmitter release probability |
| Cerebral Cortex | Layer 2/3 and Layer 5 pyramidal neurons |
| Hippocampus | CA1 and CA3 pyramidal neurons, dentate gyrus granule cells |
| Basal Ganglia | Striatal medium spiny neurons |
| Amygdala | Neurons in basal and lateral nuclei |
| Thalamus | Various thalamic nuclei |
| Cerebellum | Purkinje cells and granule cells |
| CCL3 (MIP-1α) | Pro-inflammatory chemokine, elevated in neuroinflammation |
| CCL4 (MIP-1β) | Ligand for CCR5, modulates neuronal activity |
| CCL5 (RANTES) | Chemotactic protein, affects synaptic transmission |
| Gαi signaling | Inhibits adenylate cyclase, reduces cAMP |
| MAPK pathway | Activates ERK1/2 signaling |
| PI3K/Akt pathway | Promotes cell survival |
| Calcium signaling | Modulates intracellular calcium levels |
| Chemokine production | Produce inflammatory mediators in response to activation |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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