gene

ALS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

213Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ALS4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 92 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ALS4
Full Name	Senataxin
Aliases	Alsin, Alsine
Chromosome	9q34.13
Protein Family	Superfamily 1 (SF1) DNA/RNA helicases
Function	is a rare, autosomal dominant form of amyotrophic lateral sclerosis characterized by juvenile onset and relatively slow progression.
Primary Expression	Highest in motor neurons, cerebellar Purkinje cells, hippocampal pyramidal neurons
Subcellular Localization	C-terminal Domain: Contains a SEN1N-like domain involved in transcriptional termination
Molecular Weight	185 kDa
Amino Acids	678 aa
Pathways	Autophagy, Dna Damage Response
UniProt ID	Q7Z6W4
NCBI Gene ID	29978
Ensembl ID	ENSG00000183520
OMIM	602433
GeneCards	ALS4
Human Protein Atlas	ALS4
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, Dementia
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND, BECN1, CHIP, DEMENTIA
KG Connections	211 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ALS4 — AlphaFold Q7Z6W4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    ALS4["ALS4"] -->|"associated with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    ALS4["ALS4"] -->|"associated with"| Dementia["Dementia"]
    ALS4["ALS4"] -->|"associated with"| Als["Als"]
    ALS4["ALS4"] -->|"associated with"| Ataxia["Ataxia"]
    ALS4["ALS4"] -->|"regulates"| Ms["Ms"]
    ALS4["ALS4"] -.->|"inhibits"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    ALS4["ALS4"] -->|"therapeutic target"| Stroke["Stroke"]
    ALS4["ALS4"] -->|"therapeutic target"| Als["Als"]
    ALS4["ALS4"] -->|"associated with"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    ALS4["ALS4"] -->|"associated with"| Ftd["Ftd"]
    ALS4["ALS4"] -->|"associated with"| Spinal_Muscular_Atrophy["Spinal Muscular Atrophy"]
    ALS4["ALS4"] -->|"associated with"| Stroke["Stroke"]
    style ALS4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ataxia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Frontotemporal_Dementia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ftd fill:#ef5350,stroke:#333,color:#e0e0e0
    style Spinal_Muscular_Atrophy fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (152)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
ALS	associated_with	disease	0.75
Amyotrophic Lateral Sclerosis	associated_with	disease	0.75
Als	associated_with	disease	0.75
neurons	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
ALS	causes	disease	0.70
DNA	associated_with	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.70
neurodegeneration	causes	disease	0.70
Spinocerebellar Ataxia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Ms	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ftd	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Glaucoma	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Als	inhibits	disease	0.65
Als	regulates	disease	0.65
LITAF	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
MAP1LC3	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
GENES	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
STROKE	inhibits	gene	0.60
T Cell	inhibits	cell_type	0.60
Fibroblast	inhibits	cell_type	0.60
RNA	targets	gene	0.60
WIPI2	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
P62	associated_with	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
APP	associated_with	gene	0.60
CAPN1	associated_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
ATG7	associated_with	gene	0.60

Incoming (61)

Source	Relation	Type	Str
SETX	causes	gene	0.95
SETX	causes	gene	0.95
Setx Mutation C.1166T>C	biomarker_for	biomarker	0.92
R-Loop Levels	biomarker_for	biomarker	0.90
SETX Mutations	causes	mechanism	0.90
Mutant Setx (Leu389Ser)	causes	protein	0.88
Allele-Specific Silencing	treats	process	0.85
ACTB	activates	entity	0.60
WIPI2	associated_with	gene	0.60
RNA	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
DNA	associated_with	gene	0.60
GENES	regulates	gene	0.60
DNA	therapeutic_target	gene	0.60
FIG4	associated_with	gene	0.60
FUS	associated_with	gene	0.60
ALS8	associated_with	gene	0.60
ALSIN	associated_with	gene	0.60
SETX	regulates	gene	0.60
MTORC1	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURON	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DNA	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
ALS2	associated_with	gene	0.60
RNA	therapeutic_target	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
rapamycin	targets	drug	0.60
SMN1	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
P62	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SETX	inhibits	gene	0.60
AND	regulates	gene	0.60
ALS	causes	entity	0.60
GABA	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
STROKE	therapeutic_target	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HTT	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SETX	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALS4 in their description or question text

No additional research found