ALSIN

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALSIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

ALS2/Alsin - Rab5 guanine nucleotide exchange factor involved in motor neuron disease and vesicle trafficking

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graph TD
    ALSIN["ALSIN Protein"]
    ALS2["ALS2 Gene"]
    SOD1["SOD1"]
    TARDBP["TARDBP/TDP-43"]
    FUS["FUS"]
    FIG4["FIG4"]
    
    Motor_Neurons["Motor Neurons"]
    Endosome_Trafficking["Endosome Trafficking"]
    Vesicle_Transport["Vesicle Transport"]
    Protein_Aggregation["Protein Aggregation"]
    
    ALS_Disease["Amyotrophic Lateral Sclerosis"]
    Glaucoma["Glaucoma"]
    Neurodegeneration["Neurodegeneration"]
    Gene_Mutations["Gene Mutations"]
    
    Neuroprotection["Neuroprotective Pathways"]
    Cell_Death["Motor Neuron Death"]
    
    ALS2 -->|"encodes"| ALSIN
    Gene_Mutations -->|"disrupts"| ALSIN
    
    ALSIN -->|"regulates"| Endosome_Trafficking
    ALSIN -->|"facilitates"| Vesicle_Transport
    ALSIN -->|"protects"| Motor_Neurons
    ALSIN -->|"activates"| Neuroprotection
    
    SOD1 -->|"interacts with"| ALSIN
    TARDBP -->|"co-associates with"| ALSIN
    FUS -->|"pathway crosstalk"| ALSIN
    FIG4 -->|"vesicle regulation"| ALSIN
    
    Protein_Aggregation -->|"inhibited by"| ALSIN
    Motor_Neurons -->|"degenerate in"| ALS_Disease
    Motor_Neurons -->|"affected in"| Glaucoma
    
    ALS_Disease -->|"leads to"| Neurodegeneration
    Glaucoma -->|"contributes to"| Neurodegeneration
    Protein_Aggregation -->|"causes"| Cell_Death
    Cell_Death -->|"results in"| Neurodegeneration
    
    style ALSIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style Neuroprotection fill:#1b5e20
    style Endosome_Trafficking fill:#1b5e20
    style Vesicle_Transport fill:#1b5e20
    style ALS_Disease fill:#7d4200
    style Glaucoma fill:#7d4200
    style Neurodegeneration fill:#ef5350
    style Protein_Aggregation fill:#ef5350
    style Cell_Death fill:#ef5350
    style SOD1 fill:#4a1a6b
    style TARDBP fill:#4a1a6b
    style FUS fill:#4a1a6b

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