| Gene Symbol | ALS4 |
| Full Name | Senataxin |
| Aliases | Alsin, Alsine |
| Chromosome | 9q34.13 |
| Protein Family | Superfamily 1 (SF1) DNA/RNA helicases |
| Function | is a rare, autosomal dominant form of amyotrophic lateral sclerosis characterized by juvenile onset and relatively slow progression. |
| Primary Expression | Highest in motor neurons, cerebellar Purkinje cells, hippocampal pyramidal neurons |
| Subcellular Localization | **C-terminal Domain**: Contains a SEN1N-like domain involved in transcriptional termination |
| Molecular Weight | 185 kDa |
| Amino Acids | 678 aa |
| Pathways | Autophagy, Dna Damage Response |
| UniProt ID | Q7Z6W4 |
| NCBI Gene ID | 29978 |
| Ensembl ID | ENSG00000183520 |
| OMIM | 602433 |
| GeneCards | ALS4 |
| Human Protein Atlas | ALS4 |
| Associated Diseases | Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, Dementia |
| Known Drugs/Compounds | rapamycin |
| Interactions | amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND, BECN1, CHIP, DEMENTIA |
| KG Connections | 210 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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