concept

HEXANUCLEOTIDE REPEAT EXPANSIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEXANUCLEOTIDE REPEAT EXPANSIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

173Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HEXANUCLEOTIDE REPEAT EXPANSIONS is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 68 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	HEXANUCLEOTIDE REPEAT EXPANSIONS
Key Genes/Proteins	ALS, ALZHEIMER, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
Related Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis

Pathway Diagram

graph TD
    HEXANUCLEOTIDE_REPEAT_EXPANSIO["HEXANUCLEOTIDE REPEAT EXPANSIONS"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"causes"| ALS["ALS"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"causes"| FTD["FTD"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Als["Als"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Dementia["Dementia"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| Ms["Ms"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"activates"| Neuroinflammation["Neuroinflammation"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"activates"| Inflammation["Inflammation"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| SOD1["SOD1"]
    HEXANUCLEOTIDE_REPEAT_EXPANSIO -->|"target for"| FUS["FUS"]
    ATXN2["ATXN2"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    C9ORF72["C9ORF72"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    SOD1_MUTATIONS["SOD1 MUTATIONS"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    FUS -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    SOD1 -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    ALS -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    FTLD["FTLD"] -.protects against.-> HEXANUCLEOTIDE_REPEAT_EXPANSIO
    DEMENTIA["DEMENTIA"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    GAIN["GAIN"] -->|"target for"| HEXANUCLEOTIDE_REPEAT_EXPANSIO
    ASTROCYTES["ASTROCYTES"] -->|"activates"| HEXANUCLEOTIDE_REPEAT_EXPANSIO

Outgoing (114)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HEXANUCLEOTIDE REPEAT EXPANSIONS	data_in	dataset_row	0.00
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.92
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.70
ALS	causes	disease	0.70
FTD	causes	disease	0.70
Aging	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Dementia	causes	disease	0.65
Dementia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Als	treats	disease	0.65
Ftd	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	causes	disease	0.65
Parkinson	causes	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
NEURODEGENERATIVE DISORDERS	causes	gene	0.60
GRN	causes	gene	0.60
GENES	causes	gene	0.60
APOE	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
ATP13A2	causes	gene	0.60
AUTOPHAGY	causes	gene	0.60
TMEM106B	causes	gene	0.60
ENDOSOME	causes	gene	0.60
GBA	causes	gene	0.60
PSEN1	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
Autophagy	causes	pathway	0.60

Incoming (59)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HEXANUCLEOTIDE REPEAT EXPANSIONS	data_in	dataset_row	0.00
C9ORF72	associated_with	gene	0.60
ATXN2	therapeutic_target	gene	0.60
C9ORF72	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALS	associated_with	gene	0.60
SOD1 MUTATIONS	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
AND	therapeutic_target	gene	0.60
PARKINSON	causes	gene	0.60
LYSOSOME	causes	gene	0.60
TFEB	causes	gene	0.60
TAU	causes	gene	0.60
GAIN	causes	gene	0.60
ALS	causes	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
RNA	activates	gene	0.60
AND	associated_with	gene	0.60
FTLD	protects_against	gene	0.60
MAPT	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
C9ORF72	protects_against	gene	0.60
LYSOSOME	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
C9ORF72	causes	gene	0.60
C9ORF72	treats	gene	0.60
ALS	regulates	gene	0.60
GBA	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GAIN	regulates	gene	0.60
ATP13A2	regulates	gene	0.60
TMEM106B	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
PSEN1	regulates	gene	0.60
LRRK2	regulates	gene	0.60
GRN	regulates	gene	0.60
TAU	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEXANUCLEOTIDE REPEAT EXPANSIONS in their description or question text

No additional research found