protein

PROGRANULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROGRANULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

327Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Progranulin (GRN) is a secreted growth factor involved in neuronal survival, lysosomal function, and inflammation. GRN mutations cause frontotemporal dementia and are linked to Alzheimer's and Parkinson's disease.

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🔬 Protein Info

Gene Symbol	GRN
Aliases	PROGRANULIN
Protein Family	Progranulin family
Function	is a secreted glycoprotein encoded by the <a href="/genes/grn">GRN</a> gene that functions as a crucial regulator of neuronal survival, lysosomal function, and immune response[@baker2006].
Primary Expression	Secreted, Lysosomes, Cytoplasm
Subcellular Localization	Secreted, Lysosomes, Cytoplasm
Molecular Weight	90 kDa
Amino Acids	60 aa
Pathways	Immune Response, Inflammasome, Tdp-43, Toll-Like Receptor, inflammation
UniProt ID	P28799
GeneCards	GRN
Human Protein Atlas	GRN
Associated Diseases	Als, Dementia, disease, Frontotemporal Dementia
Interactions	Actin, AGING, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections	319 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — PROGRANULIN Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

2JYE — X-ray / Cryo-EM

🔮 AI Predicted Structure

P28799 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Progranulin (PGRN)

protein · 1536 words

→

Pathway Diagram

graph TD
    PROGRANULIN["PROGRANULIN"]
    Neuroinflammation{"Neuroinflammation"}
    PROGRANULIN -->|"activates"| Neuroinflammation
    Aging{"Aging"}
    PROGRANULIN -->|"activates"| Aging
    Inflammation{"Inflammation"}
    PROGRANULIN -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    PROGRANULIN -->|"activates"| Alzheimer
    ALS{"ALS"}
    PROGRANULIN -->|"activates"| ALS
    Huntington{"Huntington"}
    PROGRANULIN -->|"activates"| Huntington
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    PROGRANULIN -->|"activates"| Frontotemporal_Dementia
    Dementia{"Dementia"}
    PROGRANULIN -->|"activates"| Dementia
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    PROGRANULIN -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Parkinson{"Parkinson"}
    PROGRANULIN -->|"activates"| Parkinson
    Prion_Disease{"Prion Disease"}
    PROGRANULIN -->|"activates"| Prion_Disease
    Neurodegeneration{"Neurodegeneration"}
    PROGRANULIN -->|"activates"| Neurodegeneration
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"activates"| PROGRANULIN
    TREM2["TREM2"]
    TREM2 -->|"activates"| PROGRANULIN
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| PROGRANULIN
    GENES["GENES"]
    GENES -->|"activates"| PROGRANULIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| PROGRANULIN
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| PROGRANULIN
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| PROGRANULIN
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| PROGRANULIN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PROGRANULIN
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| PROGRANULIN
    GPNMB["GPNMB"]
    GPNMB -->|"biomarker for"| PROGRANULIN
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"activates"| PROGRANULIN
    style PROGRANULIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (233)

Target	Relation	Type	Str
SMPD1	regulates	gene	0.90
Microglial Inflammatory Response	inhibits	process	0.85
Microglial Inflammatory Response	inhibits	process	0.85
gene- and cell-based interventions	involved_in	process	0.80
Microglia	regulates	cell_type	0.80
Neuroinflammation	inhibits	process	0.75
TDP-43	regulates	protein	0.70
astrocyte function	regulates	process	0.70
ALS	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Parkinson	activates	disease	0.65
Huntington	contributes_to	disease	0.65
Prion Disease	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Dementia	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Dementia	inhibits	disease	0.65
Huntington	activates	disease	0.65
Als	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.65
Frontotemporal Dementia	inhibits	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Aging	contributes_to	disease	0.65
Frontotemporal Dementia	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Aging	biomarker_for	disease	0.65
Prion Disease	contributes_to	disease	0.65
Inflammation	biomarker_for	disease	0.65
Dementia	causes	disease	0.65
Als	causes	disease	0.65
Ftd	causes	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	expressed_in	disease	0.65
Neurodegeneration	causes	disease	0.65
Ms	causes	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
Ftd	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Frontotemporal Dementia	biomarker_for	disease	0.65

Incoming (94)

Source	Relation	Type	Str
GRN	encodes	gene	0.70
BDNF	activates	entity	0.60
CXCL10	activates	entity	0.60
FGF21	activates	entity	0.60
FGF23	activates	entity	0.60
FNDC5	activates	entity	0.60
PLAU	activates	entity	0.60
TMEM106B	biomarker_for	gene	0.60
GJA1	activates	gene	0.60
VIMENTIN	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
APP	biomarker_for	gene	0.60
TDP-43	activates	gene	0.60
APOE	activates	gene	0.60
SLC1A2	activates	gene	0.60
SMPD1	inhibits	gene	0.60
TDP-43	expressed_in	gene	0.60
GRN	causes	gene	0.60
FUS	expressed_in	gene	0.60
GRN	associated_with	gene	0.60
DNA	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
IFN	regulates	gene	0.60
GASDERMIN	activates	gene	0.60
29249935	is reduced in	paper	0.60
AQP4	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	0.60
NEURODEGENERATIVE DISORDERS	biomarker_for	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
IGF-1	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
PGRN	activates	gene	0.60
GENES	biomarker_for	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
MICROGLIA	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
TREM2	activates	gene	0.60
CX3CR1	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
TDP-43	therapeutic_target	gene	0.60
AGING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gap 006 analysis (archived stub)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Analysis for knowledge gap 006 in the neurodegeneration domain.

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

Related Research

Hypotheses and analyses mentioning PROGRANULIN in their description or question text

No additional research found