gene 915 words KG: YBX1
Contents

YBX1 Gene

🧬 Gene Info
Gene SymbolYBX1
Full NameY-Box Binding Protein 1
Chromosome1p34.2
Functionis a multifunctional DNA- and RNA-binding protein that plays critical roles in transcriptional regulation, mRNA splicing, translation, and stress response.
Primary Expressionthe CNS: - High expression in neurons throughout the brain - Present in astrocytes and [microglia](/c
Subcellular Localizationand function
Molecular Weight36 kDa
Amino Acids70 aa
PathwaysGlycolysis, Multidrug Resistance, Nf-Κb, Wnt, mRNA Stability
UniProt IDP62962
NCBI Gene ID5102
Ensembl IDENSG00000165996
OMIM113703
GeneCardsYBX1
Human Protein AtlasYBX1
Associated DiseasesCancer
Known Drugs/Compoundsm5C, m5C-modified mRNAs, SU056
InteractionsABCB1, AGO2, AKT, ALYREF, AND, App
KG Connections148 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (7)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (13)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
BCL2 Gene
gene · KG edge: therapeutic_target
CAT — Catalase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

YBX1 activates LRP1
YBX1 regulates LRP1
YBX1 activates DRUG_RESISTANCE
SU056 inhibits YBX1
NSUN2 therapeutic_target YBX1
YBX1 interacts_with ELAVL1
LRP1 activates YBX1
YBX1 activates TCF3
TCF3 activates YBX1
GAIN activates YBX1

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