Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PEX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | PEX1 |
| Full Name | Peroxisome Biogenesis Factor 1 |
| Aliases | Page for PEX1 Gene, Page for PEX1 Protein |
| Chromosome | 7q31.2 |
| Function | PEX1 encodes an ATPase belonging to the AAA (ATPases Associated with diverse cellular Activities) family. |
| Subcellular Localization | Peroxisomal matrix |
| Molecular Weight | ~144 kDa |
| UniProt ID | P50579 |
| NCBI Gene ID | 5279 |
| Ensembl ID | ENSG00000127980 |
| GeneCards | PEX1 |
| Human Protein Atlas | PEX1 |
| Encoded Protein | Pex1p |
| Associated Diseases | neurodegeneration |
| Interactions | CAT, PEX3, YBX1 |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PEX1["PEX1"]
Als{"Als"}
PEX1 -->|"regulates"| Als
Tumor{"Tumor"}
PEX1 -->|"regulates"| Tumor
neurodegeneration["neurodegeneration"]
PEX1 -->|"implicated in"| neurodegeneration
PEX3["PEX3"]
PEX3 -->|"inhibits"| PEX1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"regulates"| PEX1
YBX1["YBX1"]
YBX1 -->|"inhibits"| PEX1
CAT["CAT"]
CAT -->|"inhibits"| PEX1
style PEX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PEX1 in their description or question text
No additional research found