gene

NSUN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSUN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

23Outgoing

14Incoming

0Experiments

0Debates

Summary

NSUN2 (NOP2/Sun RNA Methyltransferase 2) - RNA methyltransferase involved in tRNA modification, neurodevelopment, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	NSUN2
Full Name	NOP2/Sun RNA Methyltransferase 2
Chromosome	5p15.31
Protein Type	Transferase
Function	This modification occurs at specific positions within tRNA molecules, particularly at positions 34 (the wobble position) and 48 in the anticodon loop[@bhatt2019].
Primary Expression	Ubiquitous; highest in brain, testis, and gastrointestinal tract
Amino Acids	697 aa
UniProt ID	Q08J02
NCBI Gene ID	54888
Ensembl ID	ENSG00000012061
GeneCards	NSUN2
Human Protein Atlas	NSUN2
Neuronal Development	NSUN2 is highly expressed in neural progenitor cells during embryonic development, where it regulates neural stem cell proliferation and differentiation[@leong2019].
Synaptic Function	NSUN2-mediated tRNA modifications are essential for local protein synthesis at synapses, a process critical for synaptic plasticity and memory formation.
Axon Guidance	The enzyme participates in axon pathfinding through regulation of translation in growth cones.
Associated Diseases	neurodegeneration
Interactions	AGO2, ALYREF, CANCER, CTGF, ELAVL1, MMP2
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NSUN2 — AlphaFold Q08J02 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NSUN2 Gene

gene · 3064 words

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Pathway Diagram

graph TD
    NSUN2["NSUN2"]
    Cancer{"Cancer"}
    NSUN2 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    NSUN2 -->|"activates"| Carcinoma
    YBX1["YBX1"]
    NSUN2 -->|"therapeutic target"| YBX1
    ELAVL1["ELAVL1"]
    NSUN2 -->|"activates"| ELAVL1
    NSUN2 -->|"causes"| YBX1
    CANCER["CANCER"]
    NSUN2 -->|"activates"| CANCER
    AND["AND"]
    NSUN2 -->|"causes"| AND
    neurodegeneration["neurodegeneration"]
    NSUN2 -->|"implicated in"| neurodegeneration
    ELAVL1 -->|"activates"| NSUN2
    style NSUN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
Tumor Growth	promotes	phenotype	0.95
Metastasis	promotes	phenotype	0.95
Yap Mrna	upregulates	biomarker	0.92
Bladder Cancer	drives	disease	0.90
HDGF	regulates	gene	0.85
Bladder Cancer	biomarker_for	disease	0.80
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
HDGF	causes	gene	0.60
HDGF	therapeutic_target	gene	0.60
RNA	activates	gene	0.60
YBX1	interacts_with	gene	0.60
YBX1	activates	gene	0.60
YAP	activates	gene	0.60
YBX1	therapeutic_target	gene	0.60
RNA	translocates_to	gene	0.60
YBX1	regulates	entity	0.60
ELAVL1	activates	gene	0.60
YAP	regulates	gene	0.60
YAP	associated_with	gene	0.60
YAP	interacts_with	gene	0.60
YBX1	causes	gene	0.60
CANCER	activates	gene	0.60

Incoming (14)

Source	Relation	Type	Str
Yap-Tead2 Complex	upregulates	protein	0.82
YBX1	therapeutic_target	gene	0.60
CANCER	activates	gene	0.60
RNA	activates	gene	0.60
HDGF	causes	gene	0.60
YBX1	causes	gene	0.60
AGO2	activates	gene	0.60
CTGF	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
ALYREF	interacts_with	gene	0.60
ALYREF	activates	gene	0.60
ELAVL1	activates	gene	0.60
HDGF	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NSUN2 in their description or question text

No additional research found