gene

WNT7B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT7B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

29Outgoing

12Incoming

0Experiments

0Debates

Summary

WNT7B encodes a secreted glycoprotein that activates canonical β-catenin and non-canonical Wnt pathways, regulating neurodevelopment, synaptic plasticity, and neurodegenerative disease pathology.

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🧬 Gene Info

Gene Symbol	WNT7B
Full Name	Wnt Family Member 7B
Chromosome	22q13.31
Function	encodes a secreted glycoproteins that functions as a ligand in the Wnt signaling pathway, activating both canonical (β-catenin-dependent) and non-canonical (β-catenin-independent) Wnt pathways.
Primary Expression	the developing and adult brain, where it regulates critical processes including neural stem cell proliferation and differentiation, axonal guidance, s
Molecular Weight	39 kDa
Amino Acids	349 aa
Pathways	WNT, Wnt, Wnt signaling, Wnt pathway
UniProt ID	[Q9H6J4](https://www.uniprot.org/uniprot/Q9H6J4) Protein Length
Ensembl ID	ENSG00000188064
GeneCards	WNT7B
Human Protein Atlas	WNT7B
Associated Diseases	cancer
Interactions	CANCER, KRAS, MAPK, PGK1, PTEN, SMAD2
KG Connections	41 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WNT7B Gene - Wnt Family Member 7B

gene · 1913 words

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Pathway Diagram

graph TD
    WNT7B["WNT7B"]
    Pancreatic_Cancer["Pancreatic Cancer"]
    WNT7B -->|"activates"| Pancreatic_Cancer
    Cancer["Cancer"]
    WNT7B -->|"activates"| Cancer
    Tumor["Tumor"]
    WNT7B -->|"activates"| Tumor
    Carcinoma["Carcinoma"]
    WNT7B -->|"activates"| Carcinoma
    Alzheimer["Alzheimer"]
    WNT7B -->|"expressed in"| Alzheimer
    Als["Als"]
    WNT7B -->|"expressed in"| Als
    Neurodegeneration["Neurodegeneration"]
    WNT7B -->|"expressed in"| Neurodegeneration
    ALS["ALS"]
    WNT7B -->|"expressed in"| ALS
    CANCER["CANCER"]
    WNT7B -->|"activates"| CANCER
    YBX1["YBX1"]
    WNT7B -->|"activates"| YBX1
    Wnt["Wnt"]
    WNT7B -->|"activates"| Wnt
    Glycolysis["Glycolysis"]
    WNT7B -->|"activates"| Glycolysis
    GSK3["GSK3"]
    WNT7B -->|"expressed in"| GSK3
    Wnt["Wnt"]
    WNT7B -->|"expressed in"| Wnt
    AND["AND"]
    WNT7B -->|"expressed in"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    WNT7B -->|"expressed in"| ALZHEIMER_S_DISEASE
    TCF3["TCF3"]
    WNT7B -->|"expressed in"| TCF3
    PTEN["PTEN"]
    PTEN -->|"activates"| WNT7B
    PGK1["PGK1"]
    PGK1 -->|"activates"| WNT7B
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"expressed in"| WNT7B
    WNT["WNT"]
    WNT -->|"expressed in"| WNT7B
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"expressed in"| WNT7B
    Entorhinal_Cortex["Entorhinal Cortex"]
    WNT7B -->|"expressed in"| Entorhinal_Cortex
    Cortex["Cortex"]
    WNT7B -->|"expressed in"| Cortex
    Hippocampus["Hippocampus"]
    WNT7B -->|"expressed in"| Hippocampus
    Temporal_Lobe["Temporal Lobe"]
    WNT7B -->|"expressed in"| Temporal_Lobe
    neurodegeneration["neurodegeneration"]
    WNT7B -->|"implicated in"| neurodegeneration

Outgoing (29)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Als	expressed_in	disease	0.65
Pancreatic Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Wnt	activates	pathway	0.60
Wnt	expressed_in	pathway	0.60
cancer	associated_with	disease	0.60
GSK3	expressed_in	gene	0.60
App	expressed_in	protein	0.60
MAPK signaling	participates_in	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
YBX1	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Glycolysis	activates	pathway	0.60
TCF3	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
WNT	expressed_in	gene	0.60
CANCER	activates	gene	0.60
Cortex	expressed_in	brain_region	0.55
Entorhinal Cortex	expressed_in	brain_region	0.55
Temporal Lobe	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
GENE EXPRESSION	expressed_in	concept	0.50
TEMPORAL LOBE	expressed_in	concept	0.50

Incoming (12)

Source	Relation	Type	Str
KRAS	activates	gene	0.60
MAPK	activates	gene	0.60
WNT	inhibits	gene	0.60
KRAS	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
SMAD2	activates	gene	0.60
SMAD2	inhibits	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
WNT	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PTEN	activates	gene	0.60
PGK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WNT7B in their description or question text

No additional research found