gene

TRKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

943Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TRKB is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 362 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TRKB
Chromosome	9q21.33
Protein Type	Receptor
Function	is a high-affinity receptor tyrosine kinase that serves as the primary signaling receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
Subcellular Localization	</th><td>Cell membrane, endosomes, nucleus, mitochondria</td></tr>
Molecular Weight	140 kDa
Amino Acids	796 aa
Exons	24
Pathways	Akt, Apoptosis, Cell Cycle, Long-Term Potentiation, Mapk
UniProt ID	Q16620
NCBI Gene ID	4915
Ensembl ID	ENSG00000148053
GeneCards	TRKB
Human Protein Atlas	TRKB
Associated Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Cancer
Interactions	ACHE, Actin, ADAM10, AEP, AGING, AKT
KG Connections	925 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRKB — AlphaFold Q16620 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TrkB Protein

protein · 2434 words

→

TRKB Gene

gene · 1383 words

→

Pathway Diagram

flowchart TD
    BDNF["BDNF
Brain-Derived
Neurotrophic Factor"]
    TRKB["TRKB
Tropomyosin Receptor
Kinase B"]
    FGF7["FGF7
Fibroblast Growth
Factor 7"]
    
    Neurodegeneration["Neurodegeneration
General Process"]
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple
Sclerosis"]
    
    Depression["Depression
Mood Disorder"]
    Stroke["Stroke
Cerebrovascular
Event"]
    Ischemia["Ischemia
Reduced Blood
Flow"]
    Aging["Aging
Process"]
    
    Inflammation["Inflammation
Immune Response"]
    Fibrosis["Fibrosis
Tissue Scarring"]
    
    NeuroprotectiveEffects["Neuroprotective
Effects"]
    TissueRepair["Tissue Repair
 and Regeneration"]

    BDNF -->|"activates"| TRKB
    TRKB -->|"regulates"| FGF7
    TRKB -->|"promotes"| NeuroprotectiveEffects
    TRKB -->|"enhances"| TissueRepair
    
    TRKB -->|"therapeutic_target"| Neurodegeneration
    TRKB -->|"therapeutic_target"| Alzheimer
    TRKB -->|"therapeutic_target"| Parkinson
    TRKB -->|"therapeutic_target"| ALS
    TRKB -->|"therapeutic_target"| MS
    TRKB -->|"therapeutic_target"| Depression
    
    TRKB -->|"inhibits"| Aging
    TRKB -->|"inhibits"| Fibrosis
    TRKB -->|"regulates"| Inflammation
    
    Ischemia -->|"leads_to"| Stroke
    Aging -->|"contributes_to"| Neurodegeneration

    style TRKB fill:#006494
    style BDNF fill:#1b5e20
    style NeuroprotectiveEffects fill:#1b5e20
    style TissueRepair fill:#1b5e20
    style FGF7 fill:#4a1a6b
    style Neurodegeneration fill:#ef5350
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Aging fill:#5d4400
    style Depression fill:#5d4400
    style Stroke fill:#5d4400
    style Inflammation fill:#ef5350
    style Fibrosis fill:#ef5350

Outgoing (612)

Target	Relation	Type	Str
Als	activates	disease	1.00
BDNF	activates	gene	1.00
Synaptic Plasticity	activates	pathway	1.00
Inflammation	activates	disease	0.95
Depression	activates	disease	0.95
Aging	activates	disease	0.95
BDNF signaling	activates	pathway	0.92
PLC/IP3 pathway	activates	pathway	0.90
PI3K	interacts_with	gene	0.90
PI3K	interacts_with	protein	0.90
Neurotrophic Signaling	involved_in	pathway	0.90
AKT	activates	gene	0.90
DEPRESSION	activates	gene	0.90
ERK	activates	protein	0.88
Depression	therapeutic_target	disease	0.85
Neurodegeneration	activates	disease	0.85
Als	associated_with	disease	0.85
Als	regulates	disease	0.85
CREB	phosphorylates	protein	0.85
synaptic protein expression	regulates	process	0.80
DEPRESSION	therapeutic_target	gene	0.80
AGING	activates	gene	0.80
BDNF	therapeutic_target	gene	0.80
Neurogenesis	activates	pathway	0.80
TNF-Α	activates	gene	0.80
P75NTR	activates	gene	0.80
Als	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Diabetes	activates	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Neuroinflammation	activates	disease	0.75
Stroke	activates	disease	0.75
Ischemia	activates	disease	0.75
JAK	activates	gene	0.70
Pi3K/Akt	activates	pathway	0.70
INFLAMMATION	activates	gene	0.70
Differentiation	activates	pathway	0.70
Microbiota	activates	pathway	0.70
Apoptosis	activates	pathway	0.70
INFLAMMATION	therapeutic_target	gene	0.70
Oxidative Stress	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
acute lung injury	treats	disease	0.70
Oxidative Stress	regulates	pathway	0.70
EXERCISE	activates	gene	0.70
FGF7	regulates	protein	0.70
Apoptosis	regulates	pathway	0.70
BDNF	causes	gene	0.70
AKT	inhibits	gene	0.70

Incoming (331)

Source	Relation	Type	Str
BDNF	activates	protein	1.00
BDNF	associated_with	gene	1.00
LSD	binds_to	drug	0.95
psilocin	binds_to	drug	0.95
BDNF	binds_to	protein	0.95
Exercise Training	upregulates	process	0.93
AMYLOID BETA	degrades	protein	0.90
BDNF	expresses	gene	0.90
BDNF	activates	protein	0.90
TNF	activates	gene	0.90
BDNF	binds	gene	0.80
ABETA	inhibits	protein	0.80
NEURODEGENERATION	activates	gene	0.80
PI3K	activates	gene	0.80
BDNF	interacts_with	protein	0.72
TAU	therapeutic_target	gene	0.70
EXERCISE	activates	gene	0.70
ANA-12	inhibits	drug	0.70
7,8-DHF	activates	drug	0.70
BDNF	regulates	gene	0.70
STROKE	activates	gene	0.70
IL-6	activates	gene	0.70
ERK	activates	gene	0.70
BDNF	interacts_with	protein	0.70
HUNTINGTON	associated_with	gene	0.70
EPILEPSY	associated_with	gene	0.70
DEPRESSION	associated_with	gene	0.70
BAX	causes	gene	0.60
BAD	causes	gene	0.60
NPY	activates	gene	0.60
NGF	activates	gene	0.60
PSD95	activates	gene	0.60
MTOR	activates	gene	0.60
SLC17A7	expressed_in	gene	0.60
RAB7	expressed_in	gene	0.60
AKT	inhibits	gene	0.60
RAB5	expressed_in	gene	0.60
CACNA1G	expressed_in	gene	0.60
CALB1	expressed_in	gene	0.60
RAB11	expressed_in	gene	0.60
NPY	inhibits	gene	0.60
SIGMAR1	inhibits	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
TAU PATHOLOGY	protects_against	gene	0.60
MIRNAS	regulates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signa	0.610	synaptic biology	What determines the selectivity of compl
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRKB in their description or question text

No additional research found