gene

TRPC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

46Outgoing

21Incoming

0Experiments

0Debates

Summary

TRPC6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with ALS, Als, Cardiovascular. Connected to 36 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TRPC6
Chromosome	11q22.1
Protein Type	Gene
Function	encodes a non-selective calcium-permeable cation channel belonging to the TRPC (Transient Receptor Potential Canonical) family.
Primary Expression	numerous tissues, including the brain, kidney, heart, and lung, where it participates in diverse physiological processes ranging from neuronal signali
Subcellular Localization	the plasma membrane of soma and dendrites, where it contributes to synaptic plasticity, dendritic spine morphology, and
Amino Acids	931 aa
Exons	13
Pathways	PI3K
GeneCards	TRPC6
Human Protein Atlas	TRPC6
Associated Diseases	Als, calcium influx, Cardiovascular, Diabetes, Hypertension
Interactions	AKT, AND, APOPTOSIS, App, Bdnf, BDNF
KG Connections	67 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRPC6 Gene

gene · 1051 words

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Pathway Diagram

graph TD
    TRPC6["TRPC6"]
    calcium_influx["calcium influx"]
    TRPC6 -->|"causes"| calcium_influx
    Als{"Als"}
    TRPC6 -->|"associated with"| Als
    Obesity{"Obesity"}
    TRPC6 -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    TRPC6 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    TRPC6 -->|"associated with"| Diabetes
    TRPC6 -->|"associated with"| Obesity
    ALS{"ALS"}
    TRPC6 -->|"associated with"| ALS
    HCRTR1["HCRTR1"]
    TRPC6 -->|"therapeutic target"| HCRTR1
    Calcium_Signaling(["Calcium Signaling"])
    TRPC6 -->|"activates"| Calcium_Signaling
    PNOC["PNOC"]
    TRPC6 -->|"associated with"| PNOC
    HCRTR2["HCRTR2"]
    TRPC6 -->|"associated with"| HCRTR2
    neurodegeneration["neurodegeneration"]
    TRPC6 -->|"implicated in"| neurodegeneration
    NFATC1["NFATC1"]
    NFATC1 -->|"activates"| TRPC6
    HCRTR2 -->|"therapeutic target"| TRPC6
    PNOC -->|"therapeutic target"| TRPC6
    GENES["GENES"]
    GENES -->|"therapeutic target"| TRPC6
    HCRTR1 -->|"therapeutic target"| TRPC6
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"activates"| TRPC6
    HCRTR1 -->|"associated with"| TRPC6
    GENES -->|"associated with"| TRPC6
    PNOC -->|"associated with"| TRPC6
    AND["AND"]
    AND -->|"associated with"| TRPC6
    HCRTR2 -->|"associated with"| TRPC6
    style TRPC6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
calcium influx	causes	phenotype	0.90
Als	associated_with	disease	0.75
Obesity	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Sleep Disorder	therapeutic_target	disease	0.65
Hypertension	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Obesity	therapeutic_target	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
PI3K	activates	gene	0.60
MIRO1	activates	gene	0.60
TRKB	activates	gene	0.60
HCRTR2	therapeutic_target	gene	0.60
BDNF	activates	gene	0.60
Calcium Signaling	activates	pathway	0.60
FURIN	associated_with	gene	0.60
INFLAMMATION	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
Calcium Signaling	regulates	pathway	0.60
Bdnf	activates	protein	0.60
App	associated_with	protein	0.60
App	activates	protein	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
GENES	associated_with	gene	0.60
HCRTR1	therapeutic_target	gene	0.60
PNOC	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
PNOC	therapeutic_target	gene	0.60
TRPC3	activates	gene	0.60
Neuron	activates	cell_type	0.60
MITOCHONDRIA	activates	gene	0.60
AND	activates	gene	0.60
Apoptosis	inhibits	pathway	0.60
AND	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
HCRTR1	associated_with	gene	0.50
OBESITY	associated_with	disease	0.50

Incoming (21)

Source	Relation	Type	Str
NFATC1	activates	protein	0.80
PNOC	associated_with	gene	0.60
HCRTR2	associated_with	gene	0.60
BDNF	activates	gene	0.60
TRPC3	activates	gene	0.60
TRKB	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
HCRTR1	targets	gene	0.60
AKT	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
INFLAMMATION	inhibits	gene	0.60
STROKE	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
HCRTR2	targets	gene	0.60
PNOC	targets	gene	0.60
PIEZO1	activates	gene	0.60
HCRTR1	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPC6 in their description or question text

No additional research found