protein 2,434 words KG: TRKB
Contents

TrkB Protein

🔬 Protein Info
Gene SymbolTRKB
Chromosome9q21.33
Protein TypeReceptor
Functionis a high-affinity receptor tyrosine kinase that serves as the primary signaling receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
Subcellular Localization</th><td>Cell membrane, endosomes, nucleus, mitochondria</td></tr>
Molecular Weight140 kDa
Amino Acids796 aa
Exons24
PathwaysAkt, Apoptosis, Cell Cycle, Long-Term Potentiation, Mapk
UniProt IDQ16620
NCBI Gene ID4915
Ensembl IDENSG00000148053
GeneCardsTRKB
Human Protein AtlasTRKB
Associated DiseasesAging, Als, Alzheimer, Alzheimer'S Disease, Cancer
InteractionsACHE, Actin, ADAM10, AEP, AGING, AKT
KG Connections917 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (23)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
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Related Analyses (15)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (2)

Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates

Knowledge Graph (12 edges)

BDNF activates TRKB
BDNF interacts_with TRKB
MMP9 activates TRKB
TRKB activates MMP2
TRKB activates SYN3
TRKB activates MMP9
TRKB activates BDNF
BAX therapeutic_target TRKB
TRKB therapeutic_target RB1
TRKB regulates PI3K

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