concept

TAU PHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TAU PHOSPHORYLATION
Key Genes/Proteins	APOE, BDNF, CDK5, GLUT4
Related Diseases	ACETYLCHOLINE, ALZHEIMER'S DISEASE, AUTOPHAGY, CERAMIDE, DEMENTIA

Pathway Diagram

graph TD
    TAU_PHOSPHORYLATION["TAU PHOSPHORYLATION"]
    TAU_PHOSPHORYLATION -.biomarker for.-> Down_syndrome["Down syndrome"]
    TAU_PHOSPHORYLATION -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    Glucocorticoid_Receptor["Glucocorticoid Receptor"] -->|"regulates"| TAU_PHOSPHORYLATION
    Amyloid__["Amyloid-beta"] -->|"activates"| TAU_PHOSPHORYLATION
    phytochemicals["phytochemicals"] -->|"regulates"| TAU_PHOSPHORYLATION
    p38_MAPK["p38 MAPK"] -->|"activates"| TAU_PHOSPHORYLATION
    A_["Abeta"] -->|"activates"| TAU_PHOSPHORYLATION
    NPTX2["NPTX2"] -->|"target for"| TAU_PHOSPHORYLATION
    WIF1["WIF1"] -->|"target for"| TAU_PHOSPHORYLATION
    AMYLOID["AMYLOID"] -->|"regulates"| TAU_PHOSPHORYLATION
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| TAU_PHOSPHORYLATION
    AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -->|"expressed in"| TAU_PHOSPHORYLATION

Outgoing (52)

Target	Relation	Type	Str
TAU	modulates	protein	0.95
Alzheimer's Disease	contributes_to	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Neurodegeneration	contributes_to	process	0.90
Microtubule Instability	causes	phenotype	0.90
Alzheimer's Disease	drives	disease	0.85
Neuronal Degeneration	causes	process	0.85
Neurofibrillary Tangles	contributes_to	phenotype	0.85
Tau Aggregation	associated_with	process	0.85
Neurodegeneration	contributes_to	process	0.85
Alzheimer's Disease Neuropathology	contributes_to	mechanism	0.80
Alzheimer'S Disease	contributes_to	disease	0.80
Alzheimer's Disease	biomarker_for	disease	0.80
Redox Imbalance	causes	process	0.75
Down syndrome	biomarker_for	disease	0.70
SNAP25	activates	gene	0.70
AUTOPHAGY	activates	phenotype	0.70
Alzheimer's disease	causes	disease	0.70
Alzheimer's disease	biomarker_for	disease	0.70
WNT PATHWAY	regulates	pathway	0.65
AUTOPHAGY	phosphorylates	phenotype	0.65
NEURONS	interacts_with	cell_type	0.65
MAPK	inhibits	gene	0.65
ACETYLCHOLINE	regulates	phenotype	0.65
EMPAGLIFLOZIN	associated_with	drug	0.50
GSK3	regulates	concept	0.50
AMYLOID-β	regulates	concept	0.50
Infection	associated_with	disease	0.50
ORGANOIDS	associated_with	concept	0.50
Proteins	activates	protein	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
Nlrp3 Inflammasome	causes	pathway	0.50
IPSC	inhibits	concept	0.50
GLIOSIS	associated_with	concept	0.50
IPSC	expressed_in	concept	0.50
INSULIN	activates	concept	0.50
AMYLOID-β	inhibits	concept	0.50
PREFRONTAL CORTEX	associated_with	brain_region	0.50
AMYGDALA	associated_with	brain_region	0.50
INSULIN SIGNALING	associated_with	pathway	0.50
LITHIUM	associated_with	drug	0.50
VISUAL CORTEX	associated_with	brain_region	0.50
Neuron	associated_with	cell_type	0.50
Microglia	associated_with	cell_type	0.50
DAPAGLIFLOZIN	associated_with	drug	0.45
ENTORHINAL CORTEX	associated_with	brain_region	0.45
WNT SIGNALING	associated_with	pathway	0.45
WNT PATHWAY	associated_with	pathway	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45

Incoming (371)

Source	Relation	Type	Str
SYK	regulates	gene	0.95
R406	inhibits	drug	0.95
miR-219-5p	mediates	biomarker	0.95
Neddylation Inhibition	upregulates	mechanism	0.92
STING	activates	protein	0.92
Lumacaftor	inhibits	drug	0.90
BAY 61-3606	inhibits	drug	0.90
Ceramide	promotes	compound	0.90
miR-219-5p	activates	biomarker	0.90
STING	upregulates	protein	0.90
ceramide	promotes	compound	0.90
AMPK	promotes	protein	0.90
LARS2	inhibits	gene	0.90
Testosterone	inhibits	compound	0.90
TBK1	upstream_of	protein	0.88
PKR	mediates	protein	0.88
Brain Cholesterol Accumulation	promotes	phenotype	0.85
TYROBP	regulates	protein	0.85
GSK-3β	involved_in	enzyme	0.85
LRRK2	associated_with	protein	0.85
Amyloid-β	associated_with	compound	0.85
NLRP3 Inflammasome	mediates	pathway	0.85
MAPK14	mediates	protein	0.85
Lipopolysaccharide	associated_with	compound	0.85
PP2A	downregulates	protein	0.85
TTBK1	involved_in	enzyme	0.85
TBK1	mediates	protein	0.85
GMPR1	associated_with	protein	0.85
Chronic Sleep Deprivation	causes	process	0.85
GSK3B	mediates	protein	0.85
MIR-125B	upregulates	gene	0.80
amyloid-beta	promotes	protein	0.80
BDNF	disrupts	gene	0.80
MIR-132	inhibits	gene	0.80
Abeta	contributes_to	compound	0.80
MIR-212	inhibits	gene	0.80
neurons	activates	cell_type	0.80
Rg1	inhibits	compound	0.80
Hyperbaric Oxygen Therapy	inhibits	drug	0.80
GSK3B	upregulates	protein	0.80
NF-κB	modulates	protein	0.80
GMPR	modulates	gene	0.80
Oxidative Stress	upregulates	process	0.80
miR-206-3p	associated_with	compound	0.75
Glucocorticoid Receptor	regulates	receptor	0.75
autophagy	regulates	process	0.70
microglia	activates	cell_type	0.70
Aβ	activates	protein	0.70
p38 MAPK	activates	pathway	0.70
phytochemicals	regulates	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAU PHOSPHORYLATION in their description or question text

No additional research found