Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GMPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GMPR |
| Key Genes/Proteins | ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, Amyloid, AMYLOID, App |
| Related Diseases | Alzheimer, Alzheimer's Disease |
graph TD
GMPR["GMPR"]
GMPR -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
GMPR -->|"modulates"| Tau_Phosphorylation["Tau Phosphorylation"]
GMPR -->|"inhibits"| Alzheimer["Alzheimer"]
GMPR -->|"phosphorylates"| AMPK["AMPK"]
GMPR -->|"inhibits"| GSK3["GSK3"]
GMPR -->|"inhibits"| AND["AND"]
GMPR -->|"inhibits"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
GENES["GENES"] -->|"inhibits"| GMPR
AMYLOID["AMYLOID"] -->|"inhibits"| GMPR
WIF1["WIF1"] -->|"inhibits"| GMPR
ALZHEIMER["ALZHEIMER"] -->|"inhibits"| GMPR
WNT["WNT"] -->|"inhibits"| GMPR
NPTX2["NPTX2"] -->|"target for"| GMPR| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | biomarker_for | disease | 0.90 |
| Tau Phosphorylation | modulates | process | 0.80 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| GSK3 | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| NPTX2 | inhibits | gene | 0.60 |
| MET | inhibits | gene | 0.60 |
| TAU | phosphorylates | gene | 0.60 |
| Amyloid | inhibits | pathway | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Tau Phosphorylation | phosphorylates | pathway | 0.60 |
| WNT | inhibits | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| AMPK | phosphorylates | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| GSK3 | therapeutic_target | gene | 0.60 |
| Wnt | therapeutic_target | pathway | 0.60 |
| tau phosphorylation | interacts_with | process | 0.60 |
| TAU | associated_with | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| NPTX2 | therapeutic_target | gene | 0.60 |
| App | inhibits | protein | 0.60 |
| Amyloid | therapeutic_target | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMPK | associated_with | gene | 0.60 |
| NPTX2 | therapeutic_target | gene | 0.60 |
| WIF1 | therapeutic_target | gene | 0.60 |
| WNT | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| GSK3 | therapeutic_target | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| AMYLOID | inhibits | gene | 0.60 |
| WIF1 | inhibits | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| GSK3 | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GMPR in their description or question text
No additional research found