cell 1,121 words KG: ent-gene-1a8734a0
Contents

Cortical SST Detector Cells

🔬 Protein Info
Gene Symbolent-gene-1a8734a0
FunctionInput-specific dendritic inhibition
MorphologyL4 sst Martinotti interneuron (Mmus) (source: Cell Ontology)
SST (Somatostatin)The defining neuropeptide marker; acts as both neurotransmitter and modulator
SST-14/SST-28Bioactive somatostatin isoforms
GAD67 (GAD1)Glutamate decarboxylase for GABA synthesis
NPY (Neuropeptide Y)Cotransmitter, co-released with SST
NOS1 (nNOS)Neuronal nitric oxide synthase in subset of SST neurons
ReelinExtracellular protein in some subtypes
CalretininCalcium-binding protein (in specific subpopulations)
Somatostatin Receptors (SSTR1-SSTR5)Autoreceptors and drug targets
DendritesMultipolar, aspiny
AxonsLong descending axons to layer I
TargetPrimarily dendritic
Local axonal projectionsDo not extend to layer I
Firing propertyLow-threshold spiking
KG Connections8 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.87
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

Knowledge Graph (8 edges)

h-var-adc924c2d4 targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-var-adc924c2d4
h-var-b0b78b7090 targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-var-b0b78b7090
ent-gene-1a8734a0 data_in benchmark_ot_ad_answer_key:SST
benchmark_ot_ad_answer_key:SST data_in ent-gene-1a8734a0
h-3481330a targets ent-gene-1a8734a0
ent-gene-1a8734a0 targeted_by h-3481330a

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