| Gene Symbol | SST |
| Aliases | SSTPROTEIN |
| Chromosome | 3q28 |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | The SST gene encodes preprosomatostatin, which is processed to somatostatin-14 (the major form in the brain) and somatostatin-28 (predominant in the gut). |
| Mechanism of Action | Somatostatin is a peptide neurotransmitter that modulates neuronal signaling by inhibiting hormone release and neuronal excitability, with emerging evidence suggesting its potential neuroprotective role in neurodegenerative processes through regulation of inflammatory responses and synaptic plasticity. In neurodegeneration contexts, SST receptors may serve as modulators of neuroinflammatory cascades and potentially mitigate progressive neuronal damage through receptor-mediated signaling mechanisms. |
| Druggability | Low (0.41) |
| Clinical Stage | Approved |
| Amino Acids | 14 aa |
| Pathways | Amyloid, affective empathy, gamma_oscillation, neuropeptide signaling, sleep-dependent growth hormone |
| UniProt ID | P61278 |
| Ensembl ID | ENSG00000136744 |
| GeneCards | SST |
| Human Protein Atlas | SST |
| Associated Diseases | Als, Alzheimer, alzheimer_s_disease, Alzheimer's disease |
| Known Drugs/Compounds | Octreotide, Lanreotide |
| Interactions | Actin, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-Β PLAQUES |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Closed-loop transcranial focused ultrasound target Closed-loop transcranial focused ultrasound target Closed-loop focused ultrasound targeting EC-II SST (+11 more) |
| KG Connections | 457 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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