Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABAergic interneuron networks: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SST | participates_in | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gamma entrainment therapy to restore hippocampal-cortical sy | 0.851 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Alpha-gamma cross-frequency coupling enhancement to restore | 0.775 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Parvalbumin Interneuron Vulnerability Links Lactate Transpor | 0.656 | neurodegeneration | What is the molecular mechanism by which |
| Default Mode Network Circuit Stabilization | 0.627 | neuroscience | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| AD Combination Therapy Trial: Anti-Aβ + Anti-Tau | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $180,000 |
| Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lifestyle Intervention Mechanisms in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $430,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] | Han QQ, Shen SY, Liang LF, Chen XR, Yu J | Brain Behav Immun | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787] | Tomioka R, Kobayashi K, Song WJ | Neuroscience | 2026 | 0 |
| Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202] | Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh | Theranostics | 2026 | 0 |
| Plasma lipidomic fingerprinting enables high-accuracy biomarker discovery for Al [PMID:40579668] | Gao X, Cheng X, Chen P, Lin L, Wang X et | Geroscience | 2026 | 0 |
| Neuronal feedback loop of the suprachiasmatic nucleus generates robust circadian [PMID:41486279] | Wang M, Tsuno Y, Peng Y, Islam MT, Matsu | Nat Commun | 2026 | 0 |
| Effect of Physical Activity on Cognitive Function of Patients With Alzheimer's D [PMID:41609036] | Dai S, Yuan S, Zhang X, Zhong X, Jiang C | J Integr Neurosci | 2026 | 0 |
| Neuropeptide-GPCR Regulation of the Neuroimmune Axis in Neurodegeneration: Mecha [PMID:41700028] | Zhang X, Bao H, Hu J, Ren W, He Z et al. | Bioconjug Chem | 2026 | 0 |
| Machine learning-guided Huanglian Jiedu decoction targets STING in periodontitis [PMID:41760895] | Li J, Chen M, Ren P, Sun G, Zhong F et a | NPJ Digit Med | 2026 | 0 |
| Remote robotic surgery: a systematic review. [PMID:41813998] | Liu Y, Ma Z, Liu P, Zhu X, Zhao L et al. | Surg Endosc | 2026 | 0 |
| Hypothalamic clock governs circadian pain. [PMID:41855333] | Wei HR, Lou Q, Li LX, Tang L, Wu RJ et a | Science | 2026 | 0 |
| Ginseng for Cognitive Function in Elderly Adults with Mild Cognitive Impairment, [PMID:41863264] | Chen N, Yu L, Hua Q, Li B, Zheng X et al | Curr Neuropharmacol | 2026 | 0 |
| Comparative efficacy of probiotic, prebiotic, and synbiotic interventions in chi [PMID:41883407] | Yang Y, Li Y, Yan X, Huang W, Cao C et a | Front Nutr | 2026 | 0 |
| Comparison and Evaluation of Efficacy and Safety of Sitagliptin and Linagliptin [PMID:41918146] | Li L, Cui S, Chow J, Wu Y, Yu Q et al. | J Evid Based Med | 2026 | 0 |
| A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466] | Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H | Korean J Ophthalmol | 2026 | 0 |
| Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871] | Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo | Science translational medicine | 2026 | 0 |
| Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733] | Liu K, Zhang XY, Wang YT, Wang R, Jin RH | Molecular neurobiology | 2026 | 0 |
| Cftr nominates a novel therapeutic target for Alzheimer's disease: Evidence from [PMID:41401902] | Li HR, Shi JZ, Zhang MJ, Yun LY, Zhou YF | Neuropharmacology | 2026 | 0 |
| Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] | Singer Y, Yitzhaky A, Hertzberg L | Alpha psychiatry | 2026 | 0 |
| Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458] | Panzer JK, Lang AL, Levi NJ, Garcia PA, | Cell reports | 2026 | 0 |
Multi-agent debates referencing this entity