gene 1,544 words KG: SLC6A2
Contents

SLC6A2 — Norepinephrine Transporter

🧬 Gene Info
Gene SymbolSLC6A2
Full NameNorepinephrine Transporter
Chromosome16q12.2
Protein TypeTransporter
Functionis a gene encoding a critical membrane transport protein responsible for the reuptake of norepinephrine (noradrenaline) from the synaptic cleft back into presynaptic neurons.
Primary Expressionnoradrenergic neurons of the central nervous system:
Molecular Weight70 kDa
Amino Acids617 aa
PathwaysEpigenetic, autophagy pathway
UniProt ID[P23975](https://www.uniprot.org/uniprot/P23975)
Ensembl IDENSG00000170270
OMIM163910
GeneCardsSLC6A2
Human Protein AtlasSLC6A2
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Anxiety, Autism
Known Drugs/Compoundsantidepressant drugs
InteractionsActin, CACNA1B, CACNA1H, DNA, DRD1, DRD2
KG Connections200 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (8)

Noradrenergic-Tau Propagation Blockade
Score: 0.71
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66

Related Analyses (4)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_with
ADRA2A Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: associated_with
BCHE Gene - Butyrylcholinesterase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAOB associated_with SLC6A2
GABRA1 associated_with SLC6A2
CHAT associated_with SLC6A2
HMGCR associated_with SLC6A2
OPRM1 associated_with SLC6A2
SLC30A8 associated_with SLC6A2
COMT associated_with SLC6A2
NBEA associated_with SLC6A2
HTR2C associated_with SLC6A2
ADRA2A associated_with SLC6A2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)