gene

DDX3X

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX3X: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

Summary

DDX3X is a gene implicated in neurodegeneration research. Key relationships include: expressed in, inhibits, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Dementia. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DDX3X
Chromosome	Xp11.4
Function	is an ATP-dependent RNA helicase that belongs to the DEAD-box family of RNA helicases.
Molecular Weight	73 kDa
Amino Acids	662 aa
Exons	17
Pathways	NF-κB, Wnt
GeneCards	DDX3X
Human Protein Atlas	DDX3X
Associated Diseases	Als, Alzheimer, Autism, depression, neurodegeneration
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, C9ORF72, ERK1/2, G3BP1, IL-1
KG Connections	91 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DDX3X Gene

gene · 3778 words

→

DDX3X Protein

protein · 1202 words

→

Pathway Diagram

graph TD
    DDX3X["DDX3X"]
    Inflammation{"Inflammation"}
    DDX3X -->|"activates"| Inflammation
    Als{"Als"}
    DDX3X -->|"inhibits"| Als
    Neuroinflammation{"Neuroinflammation"}
    DDX3X -->|"activates"| Neuroinflammation
    Ms{"Ms"}
    DDX3X -->|"inhibits"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DDX3X -->|"inhibits"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    DDX3X -->|"inhibits"| Dementia
    Lymphoma{"Lymphoma"}
    DDX3X -->|"expressed in"| Lymphoma
    DDX3X -->|"expressed in"| Als
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    DDX3X -->|"inhibits"| AMYOTROPHIC_LATERAL_SCLEROSIS
    NEUROTOXICITY["NEUROTOXICITY"]
    DDX3X -->|"activates"| NEUROTOXICITY
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    DDX3X -->|"activates"| NEUROINFLAMMATION
    C9ORF72["C9ORF72"]
    DDX3X -->|"inhibits"| C9ORF72
    P62["P62"]
    P62 -->|"inhibits"| DDX3X
    RAN["RAN"]
    RAN -->|"regulates"| DDX3X
    CDKN2A["CDKN2A"]
    CDKN2A -->|"expressed in"| DDX3X
    TP53["TP53"]
    TP53 -->|"expressed in"| DDX3X
    TET2["TET2"]
    TET2 -->|"expressed in"| DDX3X
    MYD88["MYD88"]
    MYD88 -->|"expressed in"| DDX3X
    KMT2D["KMT2D"]
    KMT2D -->|"expressed in"| DDX3X
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DDX3X
    STAT3["STAT3"]
    STAT3 -->|"expressed in"| DDX3X
    style DDX3X fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (71)

Target	Relation	Type	Str
Dementia	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Lymphoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Autism	associated_with	disease	0.65
NLRP3	regulates	gene	0.60
STAT1	regulates	gene	0.60
TLR4	regulates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
NLRP3	activates	gene	0.60
TLR4	activates	gene	0.60
JAK2	activates	gene	0.60
STAT1	activates	gene	0.60
JAK2	regulates	gene	0.60
REL	expressed_in	gene	0.60
PRDM1	expressed_in	gene	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
RNA	regulates	gene	0.60
frontotemporal dementia	activates	disease	0.60
neurons	expressed_in	cell_type	0.60
stem cells	expressed_in	cell_type	0.60
GFP	regulates	gene	0.60
frontotemporal dementia	regulates	disease	0.60
frontotemporal dementia	expressed_in	disease	0.60
RB1	expressed_in	gene	0.60
GNA13	expressed_in	gene	0.60
ALS	inhibits	gene	0.60
ERK1/2	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
Inflammasome	inhibits	pathway	0.60
TXNRD1	expressed_in	gene	0.60
SIRT7	inhibits	gene	0.60
HSPG2	expressed_in	gene	0.60
NLRP3	inhibits	gene	0.60
Rb	expressed_in	protein	0.60
G3BP1	interacts_with	gene	0.60
depression	associated_with	disease	0.60

Incoming (20)

Source	Relation	Type	Str
NF-ΚB	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ALS	activates	gene	0.60
ALS	regulates	gene	0.60
ALS	expressed_in	gene	0.60
HSPG2	expressed_in	gene	0.60
MECP2	associated_with	gene	0.60
RNA	interacts_with	gene	0.60
P62	inhibits	gene	0.60
RAN	regulates	gene	0.60
GENES	associated_with	gene	0.60
CDKN2A	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
TET2	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
KMT2D	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
TXNRD1	expressed_in	gene	0.60
C9ORF72	activates	gene	0.60
C9ORF72	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDX3X in their description or question text

No additional research found