Contents

SIRT7 Gene

🧬 Gene Info

Gene Symbol	SIRT7
Full Name	Sirtuin 7 (Nuclear NAD-dependent deacetylase)
Aliases	SIRT7 sirtuin
Chromosome	17q25.3
Function	is a NAD+-dependent nuclear class III deacetylase predominantly localized to nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis.
Primary Expression	High in brain (cortex, hippocampus, substantia nigra), heart, liver
Subcellular Localization	nucleoli where it regulates ribosomal RNA transcription and ribosome biogenesis. It is the least characterized mammalian
Molecular Weight	44 kDa
Amino Acids	400 aa
Pathways	Apoptosis, Autophagy, Mtor, Oxidative Stress
UniProt ID	Q9H0U6
NCBI Gene ID	23433
Ensembl ID	ENSG00000117595
OMIM	613213
GeneCards	SIRT7
Human Protein Atlas	SIRT7
Associated Diseases	Aging, Cancer, Neurodegeneration
Interactions	AMPK, ATP, CDK2, DDX3X, ERK1/2, FBXO7
KG Connections	138 knowledge graph edges
Databases	GeneCards HPA STRING

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