gene 1,417 words KG: SIRT2
Contents

SIRT2 Gene

🧬 Gene Info
Gene SymbolSIRT2
Full NameSirtuin 2
Chromosome19q13.32
FunctionThis function is critical for
Primary Expressionboth cytoplasmic and nuclear compartments
Subcellular Localization**Primary**: Cytoplasm, where it deacetylates alpha-tubulin
Molecular Weight43 kDa
Amino Acids389 aa
Exons13 coding exons
PathwaysAutophagy, Necroptosis, Oxidative Stress
UniProt IDQ8IXJ6
NCBI Gene ID22933
Ensembl IDENSG00000145335
OMIM604479
GeneCardsSIRT2
Human Protein AtlasSIRT2
Associated Diseasesaging, ALS, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsMMP9_IN1
InteractionsAGING, AIM2, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections284 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (20)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Sirtuin Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits

Knowledge Graph (12 edges)

MMP9_IN1 activates SIRT2
SIRT2 activates NRF2
MMP9 regulates SIRT2
SIRT2 regulates NRF2
SIRT2 regulates MMP9
SIRT6 associated_with SIRT2
HDAC11 regulates SIRT2
HDAC2 regulates SIRT2
SIRT7 expressed_in SIRT2
SIRT5 expressed_in SIRT2

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