gene 993 words KG: SGK1
Contents

SGK1 Gene

🧬 Gene Info
Gene SymbolSGK1
Chromosome6q23
Protein TypeKinase
FunctionSGK1 is a member of the AGC kinase family (PKA/PKB/PKC-related) with diverse cellular functions: [@firestone2003]
Molecular Weight49 kDa
Amino Acids433 aa
Exons13
PathwaysmTOR, mtor
GeneCardsSGK1
Human Protein AtlasSGK1
SGK1 isoform 1Full-length protein (433 amino acids)
SGK1 isoform 2Truncated variant with alternative start site
SGK1 isoform 3Tissue-specific expression pattern
Associated DiseasesAls, Depression, Inflammation, Lymphoma, Ms
InteractionsAND, BDNF, CD4, CREB, CYTOKINES, DNA
KG Connections69 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.88
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Multi-Modal Stress Response Harmonization
Score: 0.76
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
Genes
index · KG edge: activates
A2M Gene
gene · KG edge: associated_with
AQP4 (Aquaporin-4 Gene)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SGK1 associated_with FKBP5
SGK1 associated_with A2M
SGK1 associated_with AQP4
SGK1 associated_with TNF
SGK1 associated_with P2RX7
SGK1 associated_with ISG15
SGK1 associated_with STAT1
SGK1 associated_with USP18
SGK1 associated_with CXCL12
BCL2 associated_with SGK1

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