| Gene Symbol | SFPQ |
| Full Name | Splicing Factor Proline and Glutamine Rich |
| Chromosome | 1p35.3 |
| Protein Type | RNA-binding protein, Splicing factor |
| Function | encodes a nuclear RNA-binding protein that functions as a critical regulator of alternative splicing, transcriptional regulation, and RNA processing. |
| Molecular Weight | 76 kDa |
| Amino Acids | 664 aa |
| Pathways | Alpha-Synuclein, Er Stress, Synaptic Plasticity |
| UniProt ID | [P23246](https://www.uniprot.org/uniprot/P23246) |
| Ensembl ID | ENSG00000116560 |
| OMIM | 605199 |
| GeneCards | SFPQ |
| Human Protein Atlas | SFPQ |
| N-terminal domain | Contains multiple proline-rich motifs that mediate protein-protein interactions |
| RNA recognition motif (RRM) domains | Two RRM domains that bind RNA and single-stranded DNA |
| Associated Diseases | Als, Alzheimer, Parkinson |
| Interactions | ALZHEIMER, APOE, APP, CALB1, CCNF, CCT4 |
| KG Connections | 124 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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