protein

NONO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NONO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

8Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for NONO Protein

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🔬 Protein Info

Gene Symbol	NONO
Full Name	Non-POU Domain Containing Octamer Binding
Chromosome	Xq13.1
Protein Type	RNA-binding protein, DBHS family
Function	encodes a nuclear RNA-binding protein that belongs to the DBHS (Drosophila Behavior and Human Splicing) protein family.
Molecular Weight	54 kDa
UniProt ID	[Q13435](https://www.uniprot.org/uniprot/Q13435)
Ensembl ID	ENSG00000147140
OMIM	300084
GeneCards	NONO
Human Protein Atlas	NONO
N-terminal region	Involved in protein-protein interactions
DBHS domain	Conserved region comprising two RNA recognition motifs (RRMs) and an HTH (helix-turn-helix) domain
C-terminal region	Mediates multimerization and nuclear localization
SFPQ-NONO heterodimer	Primary functional complex for RNA processing
Associated Diseases	neurodegeneration
Interactions	CANCER, FMR1, FUS, G3BP1, MUC1, MYC
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NONO Gene

gene · 1219 words

→

NONO Protein

protein · 639 words

→

Pathway Diagram

graph TD
    NONO["NONO"]
    Ms{"Ms"}
    NONO -->|"interacts with"| Ms
    Cancer{"Cancer"}
    NONO -->|"interacts with"| Cancer
    CANCER["CANCER"]
    NONO -->|"interacts with"| CANCER
    SQSTM1["SQSTM1"]
    NONO -->|"interacts with"| SQSTM1
    FMR1["FMR1"]
    NONO -->|"interacts with"| FMR1
    SND1["SND1"]
    NONO -->|"interacts with"| SND1
    neurodegeneration["neurodegeneration"]
    NONO -->|"implicated in"| neurodegeneration
    NPM1["NPM1"]
    NPM1 -->|"interacts with"| NONO
    G3BP1["G3BP1"]
    G3BP1 -->|"interacts with"| NONO
    style NONO fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
SQSTM1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SND1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
RNA	activates	gene	0.60
SFPQ	activates	gene	0.60

Incoming (5)

Source	Relation	Type	Str
NPM1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
FUS	activates	gene	0.60
MUC1	activates	gene	0.60
MYC	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NONO in their description or question text

No additional research found