| Gene Symbol | ROCK1 |
| Full Name | Rho Associated Coiled-Coil Containing Protein Kinase 1 |
| Chromosome | 18q11.1 |
| Protein Type | Serine/Threonine Kinase |
| Function | ROCK1 encodes a serine/threonine kinase that is a major effector of Rho GTPases. |
| Primary Expression | human tissues, with particularly high expression in the brain, where it regulates cytoskeletal dynamics essential for neuronal function and connectivi |
| Molecular Weight | 158 kDa |
| Amino Acids | 354 aa |
| Pathways | Akt, Apoptosis, Autophagy, Mtor, Oxidative Stress |
| UniProt ID | [Q13464](https://www.uniprot.org/uniprot/Q13464) |
| Ensembl ID | ENSG00000067900 |
| OMIM | 601703 |
| GeneCards | ROCK1 |
| Human Protein Atlas | ROCK1 |
| N-terminal kinase domain | Catalytic serine/threonine kinase activity (~300 aa) |
| Associated Diseases | ALS, Alzheimer, neurodegeneration |
| Interactions | AKT, APOPTOSIS, APP, APP/PS1, AUTOPHAGY, BRAIN INJURY |
| KG Connections | 101 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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