gene

CFH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

44Outgoing

26Incoming

0Experiments

0Debates

Summary

CFH is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, implicated in. Associated with Aging, Als, Alzheimer. Connected to 45 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CFH
Chromosome	1q31.3
Function	Factor H functions as the main soluble regulator of the alternative complement pathway
Amino Acids	121 aa
Pathways	Complement, Autophagy, Akt, Phagocytosis, Mitochondrial Function
Ensembl ID	ENSG00000005381
GeneCards	CFH
Human Protein Atlas	CFH
N-terminal domains (1-4)	Mediate decay-accelerating and cofactor activity
Central domains (5-7)	Bind C3b and C3d
C-terminal domains (18-20)	Mediate host surface recognition and attachment
Associated Diseases	Als, Alzheimer, Atherosclerosis, Heart Failure, Neurodegeneration, Senescence
Interactions	AGING, AKT2, AUTOPHAGY, BMAL1, C1S, C3
KG Connections	70 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CFH

gene · 882 words

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Pathway Diagram

graph TD
    CFH["CFH"]
    Neurodegeneration{"Neurodegeneration"}
    CFH -->|"associated with"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    CFH -->|"associated with"| Alzheimer
    Aging{"Aging"}
    CFH -->|"activates"| Aging
    Complement(["Complement"])
    CFH -->|"associated with"| Complement
    C1S["C1S"]
    CFH -->|"associated with"| C1S
    RS6664877["RS6664877"]
    CFH -->|"associated with"| RS6664877
    GENES["GENES"]
    CFH -->|"associated with"| GENES
    CR1["CR1"]
    CFH -->|"associated with"| CR1
    AKT2["AKT2"]
    CFH -->|"activates"| AKT2
    COMPLEMENT["COMPLEMENT"]
    CFH -->|"activates"| COMPLEMENT
    TFE3["TFE3"]
    CFH -->|"activates"| TFE3
    AUTOPHAGY["AUTOPHAGY"]
    CFH -->|"activates"| AUTOPHAGY
    CLU["CLU"]
    CLU -->|"associated with"| CFH
    C1S -->|"associated with"| CFH
    CLUSTERIN["CLUSTERIN"]
    CLUSTERIN -->|"associated with"| CFH
    C1Q["C1Q"]
    C1Q -->|"associated with"| CFH
    CR1 -->|"associated with"| CFH
    RS6656401["RS6656401"]
    RS6656401 -->|"associated with"| CFH
    RS3919533["RS3919533"]
    RS3919533 -->|"associated with"| CFH
    AGING["AGING"]
    AGING -->|"activates"| CFH
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| CFH
    style CFH fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
Aging	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
stem cells	expressed_in	cell_type	0.60
CLU	associated_with	gene	0.60
RS6664877	associated_with	gene	0.60
C1S	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Epigenetic	associated_with	pathway	0.60
Complement	associated_with	pathway	0.60
GENES	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Phagocytosis	activates	pathway	0.60
Mitochondrial Function	activates	pathway	0.60
Complement	activates	pathway	0.60
CR1	associated_with	gene	0.60
AKT2	activates	gene	0.60
TFE3	activates	gene	0.60
SIRT5	activates	gene	0.60
TFEB	activates	gene	0.60
CLUSTERIN	implicated_in	gene	0.60
C1Q	associated_with	gene	0.60
CR1	interacts_with	gene	0.60
complement cascade	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.55
TNF	activates	gene	0.55
circadian regulation	participates_in	pathway	0.55
LIMK1	activates	gene	0.55
ROCK1	activates	gene	0.55
RNA	activates	gene	0.55
oxidative stress response	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
TIMP1	activates	gene	0.55

Incoming (26)

Source	Relation	Type	Str
IL10	associated_with	gene	0.60
TP53	associated_with	gene	0.60
APOE	associated_with	gene	0.60
IL6	associated_with	gene	0.60
IL17A	associated_with	gene	0.60
CLUSTERIN	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
CR1	associated_with	gene	0.60
C1S	interacts_with	gene	0.60
CLU	associated_with	gene	0.60
C1S	associated_with	gene	0.60
AKT2	activates	gene	0.60
RS6664877	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
RS6656401	associated_with	gene	0.60
RS3919533	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AGING	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
BMAL1	activates	gene	0.55
C3	activates	gene	0.55
CD55	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CFH in their description or question text

No additional research found