| Gene Symbol | PRDX1 |
| Aliases | Peroxiredoxin 1 |
| Function | Peroxiredoxin 1 is a ubiquitous antioxidant enzyme |
| Subcellular Localization | ** | Cytoplasm, nucleus, mitochondria | |
| Molecular Weight | 22 kDa |
| Amino Acids | 199 aa |
| Pathways | GLYCOLYSIS |
| UniProt ID | PRDX1 |
| Ensembl ID | ENSG00000117450 |
| GeneCards | PRDX1 |
| Human Protein Atlas | PRDX1 |
| N-Terminal Resolving Cysteine (Cys52) | The first conserved cysteine that forms a disulfide bond with the C-terminal cysteine during the catalytic cycle. This residue is essential for peroxidase activity. |
| C-Terminal Resolving Cysteine (Cys173) | The second critical cysteine that forms an intersubunit disulfide bond in the dimeric protein. This forms the characteristic 2-Cys peroxiredoxin disulfide. |
| Active Site FVCP Motif (aa 49-52) | The conserved motif containing the N-terminal resolving cysteine. This motif is critical for nucleophilic attack on peroxides. |
| Thioredoxin Fold | The characteristic three-dimensional structure shared with thioredoxin and glutaredoxin families, providing the structural basis for redox activity. |
| Associated Diseases | Lymphoma, Tumor |
| Known Drugs/Compounds | Lipopolysaccharide, LPS |
| Interactions | AKT, AND, APOPTOSIS, ARHGEF2, AUTOPHAGY, BECN1 |
| KG Connections | 175 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!