| Gene Symbol | PRDX1PROTEIN |
| Full Name | Peroxiredoxin 1 |
| Protein Family | Peroxiredoxin family (2-Cys typical) |
| Function | is a member of the peroxiredoxin family of antioxidant proteins that catalyze the reduction of hydrogen peroxide (H₂O₂), organic hydroperoxides, and peroxynitrite. |
| Primary Expression | Ubiquitous, highest in brain, liver, kidney |
| Molecular Weight | 22 kDa (199 amino acids) |
| Amino Acids | 199 aa |
| UniProt ID | Q06830 |
| GeneCards | PRDX1PROTEIN |
| Human Protein Atlas | PRDX1PROTEIN |
| N-terminal region | Contains the resolving cysteine (Cys⁵¹) critical for catalytic activity |
| C-terminal region | Harbors the peroxidatic cysteine (Cys¹⁷²) that initiates the peroxide reduction reaction |
| Conserved FFYPGW motif | Located in the active site pocket, essential for substrate binding |
| Decameric assembly | At high concentrations, PRDX1 dimers associate into ring-like decamers (10-mers) that enhance its chaperone activity |
| Associated Diseases | Lymphoma, Tumor |
| Known Drugs/Compounds | Lipopolysaccharide, LPS |
| Interactions | AKT, AND, APOPTOSIS, ARHGEF2, AUTOPHAGY, BECN1 |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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