gene 2,764 words KG: PDPK1
Contents

PDPK1 Gene

🧬 Gene Info
Gene Symbol**PDPK1**
Full Name3-Phosphoinositide Dependent Protein Kinase 1
Chromosome16p13.3
Protein TypeSerine/Threonine Kinase
Functionencodes a serine/threonine kinase that serves as the master activator of the AKT signaling pathway and other AGC family kinases.
PathwaysPI3K, pi3k
UniProt IDO15530
NCBI Gene ID5170
Ensembl IDENSG00000124151
OMIM605363
Associated DiseasesInfection
InteractionsAKT, AKT1, CANCER, DNA, EGFR, EIF4EBP1
KG Connections68 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (12)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: associated_with
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

BCL2 associated_with PDPK1
ATG14 associated_with PDPK1
MTOR associated_with PDPK1
BECN1 associated_with PDPK1
SQSTM1 associated_with PDPK1
PDPK1 associated_with PIK3C3
PDPK1 associated_with LC3
FOXO1 expressed_in PDPK1
AKT activates PDPK1
AKT1 expressed_in PDPK1

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