Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:FN | data_in | dataset_row | 0.00 |
| NLGN1 | regulates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:FN | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.724 | neurodegeneration | How do the seven novel ALS genes functio |
| Microglial IFN-β Priming of Motor Neuron cGAS/STING Amplific | 0.720 | neurodegeneration | What determines the specificity of TDP-4 |
| Matrix Stiffness Normalization via Targeted Lysyl Oxidase In | 0.709 | neurodegeneration | Perivascular spaces and glymphatic clear |
| Extracellular Matrix Stiffness Modulation | 0.691 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| DRP1 S616 Hyperphosphorylation and MFN2 Downregulation Creat | 0.680 | neurodegeneration | - |
| MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction | 0.644 | neurodegeneration | What upstream mechanisms cause TDP-43 to |
| MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync | 0.615 | neurodegeneration | How do different organelle-specific auto |
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.601 | neuroinflammation | What molecular mechanisms drive the tran |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Endothelium-specific TBK1 knockdown in atherosclerosis model | validation | atherosclerosis | 0.900 | 0.00 | endothelium-specific TBK1 knoc | proposed | N/A |
| TBK1-PAK1IP1-PAK1 signaling pathway analysis | exploratory | atherosclerosis | 0.900 | 0.00 | endothelial cells | proposed | N/A |
| Microglial activation by bEVs via Piezo1 | exploratory | Alzheimer's disease | 0.900 | 0.00 | microglia (in vivo and in vitr | proposed | N/A |
| GSK8612 treatment in atherosclerosis model | validation | atherosclerosis | 0.800 | 0.00 | atherosclerosis mouse model | proposed | N/A |
| LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries | exploratory | atherosclerosis | 0.800 | 0.00 | mouse and human arteries with | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720] | Harraz OF, Hashad AM | Physiology (Bethesda) | 2026 | 1 |
| Evolutionary conservation and Immunoregulatory function of LOXL3 gene in lamprey [PMID:40816690] | Pang Y, Yan Z, Gao Y, Li D, Zhao L, Ma G | Fish Shellfish Immunol | 2025 | 1 |
| Machine learning-based in-silico analysis identifies signatures of lysyl oxidase [PMID:40186284] | Xu Q, Ma L, Streuer A, Altrock E, Schmit | Cell Commun Signal | 2025 | 1 |
| Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160] | Wang Y, Wang J, Zhang J, Wang Y, Wang Y, | Sci Adv | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296] | Jiang Y, Zhang H, Wang J, Liu Y, Luo T, | J Hematol Oncol | 2022 | 1 |
| Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671] | Atcha H, Jairaman A, Holt JR, Meli VS, N | Nat Commun | 2021 | 1 |
| Restricting intracellular Salmonella proliferation by coordinating p-TBK1 mediat [PMID:40660474] | Li J, Yang Y, Ge Y, Zhang X, Liu H et al | Autophagy | 2026 | 0 |
| Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920] | Sun H, Wu Z, Zhang Y, Liu C, Gao D et al | Osteoarthritis Cartilage | 2026 | 0 |
| Aberrant STING signalling promotes endothelial dysfunction and neurovascular inj [PMID:41419617] | Qin X, Chen S, Sun Y, Ma Z, Niu C et al. | Diabetologia | 2026 | 0 |
| TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons. [PMID:41485128] | Mordes DA, Smeyers J | Autophagy | 2026 | 0 |
| Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513] | Ma J, Xie N, Wang Z, Liang X, Han Y et a | Adv Sci (Weinh) | 2026 | 0 |
| Dynamic regulation of TBK1 lactylation shapes antiviral immune responses. [PMID:41530535] | Xie Y, Zhang Y, Peng W, Zhang L, Hu Z et | Cell Mol Immunol | 2026 | 0 |
| Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798] | Zhang M, Ge Y, Wang Z, Li H, Wang G et a | Neurosci Biobehav Rev | 2026 | 0 |
| Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045] | Pillai EK, Mukherjee S, Gampl N, McGinn | Nat Mater | 2026 | 0 |
| RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodege [PMID:41603250] | Naumann M, Wierschin TM, Kretschmer S, D | Adv Sci (Weinh) | 2026 | 0 |
| BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic [PMID:41710977] | Liu Q, Zhang X, Wang L, Chen H, Wang G e | Brain | 2026 | 0 |
| The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354] | Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a | MedComm (2020) | 2026 | 0 |
| Systematic Review: Porphyromonas gingivalis Outer Membrane Vesicles From Pathoge [PMID:41980468] | Li Z, Luo C, Wen P, Zou T, Jin Z et al. | Int Dent J | 2026 | 0 |
| Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] | ["Li R", "Xia J", "Shi C", "Zhang K", "Q | Journal of advanced research | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FN in their description or question text
Score: 0.644 · neurodegeneration · 2026-04-21
## Mechanistic Overview MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction starts from the claim that modulating
Score: 0.615 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The mitochondria-associated ER membranes (MAMs) represent specialized microdomain
Score: 0.601 · neuroinflammation · 2026-04-15
## Mechanistic Overview STING Antagonism Prevents Acute-to-Chronic Neuroinflammation Transition via Interruption of IFN-