concept

MTOR SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

380Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MTOR SIGNALING
Key Genes/Proteins	ACSL4, AKT, AKT1, ALZHEIMER, AMPK, APOE
Related Diseases	aging, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    MTOR_SIGNALING["MTOR SIGNALING"]
    MTOR_SIGNALING -->|"involved_in"| Ovarian_Aging["Ovarian Aging"]
    MTOR_SIGNALING -->|"regulates"| PI3K["PI3K"]
    MTOR_SIGNALING -->|"involved_in"| Maternal_Microbiome_Effects_on["Maternal Microbiome Effects on Stem Cells"]
    MTOR_SIGNALING -->|"regulates"| Motor_Function["Motor Function"]
    MTOR_SIGNALING -->|"upregulates"| Dendritic_Spine_Density["Dendritic Spine Density"]
    MTOR_SIGNALING -.protects against.-> Neurodegeneration["Neurodegeneration"]
    MTOR_SIGNALING -->|"modulates"| Synaptic_Function["Synaptic Function"]
    TSC2["TSC2"] -->|"inhibits"| MTOR_SIGNALING
    mTORC1["mTORC1"] -->|"activates"| MTOR_SIGNALING
    AKT["AKT"] -->|"regulates"| MTOR_SIGNALING
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| MTOR_SIGNALING
    RB1CC1_knockdown["RB1CC1 knockdown"] -->|"inhibits"| MTOR_SIGNALING
    Paeoniflorin["Paeoniflorin"] -->|"downregulates"| MTOR_SIGNALING
    Sandhoff_Disease["Sandhoff Disease"] -->|"downregulates"| MTOR_SIGNALING

Outgoing (129)

Target	Relation	Type	Str
PI3K	regulates	gene	0.95
Maternal Microbiome-Mediated Stem Cell Effects	mediates	mechanism	0.95
Ovarian Aging	involved_in	process	0.95
PI3K	activates	gene	0.95
Ovarian aging	regulates	process	0.90
Maternal Microbiome Effects on Stem Cells	involved_in	process	0.90
Alzheimer Disease	involved_in	disease	0.90
Microglial Metabolic Fitness	regulates	phenotype	0.88
Dendritic Spine Density	upregulates	phenotype	0.85
Neurodegeneration	protects_against	process	0.85
Brain Cells	associated_with	cell_type	0.85
Motor Function	regulates	phenotype	0.85
Synaptic Function	modulates	process	0.80
autophagy-lysosome function	inhibits	process	0.70
TBK1	targets	gene	0.65
ACSL4	targets	gene	0.65
STING	targets	gene	0.65
EPITHELIAL-MESENCHYMAL TRANSITION	treats	phenotype	0.65
STEM CELLS	regulates	cell_type	0.65
PI3K	therapeutic_target	gene	0.65
GLYCOLYSIS	regulates	phenotype	0.65
JNK	stabilizes	gene	0.60
DENTATE GYRUS	associated_with	brain_region	0.50
T CELLS	associated_with	cell_type	0.50
LDLR	associated_with	gene	0.50
CURCUMIN	activates	concept	0.50
FIBROBLASTS	associated_with	cell_type	0.50
PDGF	associated_with	gene	0.50
SYK	associated_with	gene	0.50
SIRT1	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
OXIDATIVE STRESS	activates	process	0.50
APOE	associated_with	gene	0.50
PI3K	inhibits	gene	0.50
PI3K	causes	gene	0.50
HEPATOCYTES	activates	concept	0.50
NEURODEGENERATION	regulates	process	0.50
FIBROSIS	associated_with	disease	0.45
SNAP25	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
CELL DEATH	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
STROKE	associated_with	disease	0.45
STEM CELLS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
HEPATOCYTES	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
NEUROINFLAMMATION	inhibits	disease	0.45
BCL2	associated_with	gene	0.45
BAX	associated_with	gene	0.45

Incoming (251)

Source	Relation	Type	Str
AUTOPHAGY	activates	process	0.95
AKT	activates	gene	0.95
mTORC1	activates	protein	0.95
TSC2	inhibits	gene	0.95
AKT	regulates	gene	0.95
Paeoniflorin	downregulates	compound	0.90
Sandhoff Disease	associated_with	disease	0.90
Sandhoff Disease	downregulates	disease	0.90
NTN1 EC-EXO	activates	compound	0.90
RB1CC1 knockdown	inhibits	phenotype	0.90
STAU2	involved_in	protein	0.85
Dectin-1	activates	receptor	0.82
TSC1	regulates	gene	0.80
SEMA3F	inhibits	gene	0.80
APOE4	activates	gene	0.70
STAU1	activates	protein	0.70
AKT	inhibits	gene	0.65
AKT	therapeutic_target	gene	0.65
APOPTOSIS	activates	process	0.65
MTOR	inhibits	gene	0.65
AUTOPHAGY	treats	phenotype	0.65
BAICALEIN	inhibits	drug	0.65
CANCER	activates	disease	0.65
TREM2	inhibits	gene	0.65
Dna Methylation	associated_with	pathway	0.50
AMPK	activates	gene	0.50
Pi3K	activates	pathway	0.50
CELL PROLIFERATION	activates	process	0.50
MTOR	activates	gene	0.50
CUL3	associated_with	gene	0.50
mTOR	activates	entity	0.50
AGING	regulates	process	0.50
KEAP1	associated_with	gene	0.50
NRF2	associated_with	gene	0.50
Pi3K/Akt	activates	pathway	0.50
mTOR	inhibits	entity	0.50
SYNAPSE	interacts_with	concept	0.50
ferroptosis	inhibits	phenotype	0.50
late	interacts_with	disease	0.50
mTOR	interacts_with	entity	0.50
AKT	causes	gene	0.50
Endocytosis	interacts_with	pathway	0.50
Microrna	inhibits	pathway	0.50
AUTOPHAGY	regulates	process	0.50
mTOR	associated_with	entity	0.50
cardiomyopathy	inhibits	disease	0.50
cancer	associated_with	disease	0.50
Pi3K	associated_with	pathway	0.50
Prostate Cancer	associated_with	disease	0.50
FERROPTOSIS	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning MTOR SIGNALING in their description or question text

No additional research found