process

Epithelial-Mesenchymal Transition

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Epithelial-Mesenchymal Transition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

294Connections

0Hypotheses

0Analyses

19Outgoing

50Incoming

0Experiments

0Debates

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🧬 Biological Process Info

Name	Epithelial-Mesenchymal Transition
Key Genes/Proteins	AGING, AKT, AMPK, APOE, APOPTOSIS, ASCL1
Related Diseases	acetylcholine, Aging, Als
Related Pathways	Akt/Mtor

Pathway Diagram

graph TD
    Epithelial_Mesenchymal_Transit["Epithelial-Mesenchymal Transition"]
    Esophageal_Squamous_Cell_Carci{"Esophageal Squamous-Cell Carcinoma"}
    Epithelial_Mesenchymal_Transit -->|"contributes_to"| Esophageal_Squamous_Cell_Carci
    CANCER(["CANCER"])
    CANCER -->|"activates"| Epithelial_Mesenchymal_Transit
    Tumor{"Tumor"}
    Tumor -->|"therapeutic_target"| Epithelial_Mesenchymal_Transit
    Cancer{"Cancer"}
    Cancer -->|"activates"| Epithelial_Mesenchymal_Transit
    PI3K(["PI3K"])
    PI3K -->|"regulates"| Epithelial_Mesenchymal_Transit
    style Epithelial_Mesenchymal_Transit fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
renal fibrosis	promotes	disease	0.90
Esophageal Squamous-Cell Carcinoma	contributes_to	disease	0.90
Cancer Metastasis	contributes_to	phenotype	0.90
Esophageal Squamous Cell Carcinoma	contributes_to	disease	0.90
Nasopharyngeal Carcinoma metastasis	associated_with	phenotype	0.90
Cancer Proliferation	contributes_to	phenotype	0.85
Cancer Invasion	contributes_to	phenotype	0.85
Esophageal Squamous Cell Carcinoma	promotes	disease	0.85
CANCER	exacerbates	disease	0.65
CELL MIGRATION	activates	concept	0.50
MTOR SIGNALING	activates	concept	0.50
CELL PROLIFERATION	activates	concept	0.50
METFORMIN	inhibits	concept	0.50
PI3K/AKT PATHWAY	associated_with	pathway	0.50
EXTRACELLULAR MATRIX	activates	concept	0.50
Proteins	associated_with	protein	0.50
METFORMIN	associated_with	drug	0.45
MTOR SIGNALING	associated_with	pathway	0.45
LUTEOLIN	associated_with	drug	0.45

Incoming (275)

Source	Relation	Type	Str
AKT	regulates	gene	1.00
CANCER	activates	gene	1.00
AKT	activates	gene	1.00
Cancer	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
PI3K	regulates	gene	1.00
Tumor	activates	disease	1.00
AUTOPHAGY	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
EFNB1	associated_with	gene	0.95
Netrin-1 Blockade	inhibits	mechanism	0.95
EPHB4	associated_with	gene	0.95
Notch Signaling Pathway	associated_with	pathway	0.95
NTN1	inhibits	gene	0.95
mitochondrial dysfunction	triggers	phenotype	0.90
Netrin-1 Inhibitor	suppresses	drug	0.90
NTN1	promotes	protein	0.90
LRP1	associated_with	gene	0.90
β-Adrenergic Signaling	associated_with	pathway	0.90
FLOT1	modulates	protein	0.90
SATB2	inhibits	protein	0.90
Cancer	inhibits	disease	0.90
MTOR	regulates	gene	0.90
CANCER	inhibits	gene	0.90
APOPTOSIS	activates	gene	0.90
Breast Cancer	inhibits	disease	0.90
Carcinoma	activates	disease	0.90
NTN1	drives	protein	0.88
Ononin	inhibits	compound	0.88
Beta-adrenergic Signaling	associated_with	pathway	0.85
PI3K/AKT pathway	drives	pathway	0.85
Metformin	inhibits	drug	0.85
E-cadherin	involved_in	protein	0.85
NTN1 blockade	inhibits	drug	0.85
Luteolin	inhibits	compound	0.85
Akt/Mtor	activates	pathway	0.85
TUBB3	promotes	gene	0.85
FBXO32	promotes	protein	0.85
autophagy	promotes	process	0.85
PI3K/AKT	regulates	pathway	0.85
PARKIN	inhibits	protein	0.84
R-loop dysregulation	activates	process	0.80
Autophagy	regulates	process	0.80
autophagy	inhibits	process	0.80
NP137	inhibits	drug	0.80
Autophagy	involved_in	process	0.80
Cancer	associated_with	disease	0.80
CANCER	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Epithelial-Mesenchymal Transition in their description or question text

No additional research found