Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Vagus Nerve: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Microbiota-Gut-Brain Axis | mediates | pathway | 0.90 |
| Alpha-Synuclein Spread | mediates | process | 0.85 |
| Sepsis-Associated Encephalopathy | mediates | disease | 0.85 |
| Gut-Brain Axis | component_of | pathway | 0.85 |
| gut microbiota | interacts_with | process | 0.85 |
| Hepatic Lipogenesis | mediates | process | 0.80 |
| Gut-Brain Communication | mediates | pathway | 0.75 |
| TNF | regulates | protein | 0.70 |
| gut-brain anti-inflammatory signaling | regulates | process | 0.70 |
| gut-brain axis | regulates | pathway | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Microbiota | interacts_with | process | 0.90 |
| SDA-2026-04-01-gap-20260401-225155 | involves | analysis | 0.85 |
| α-Synuclein | interacts_with | protein | 0.75 |
| 31730854 | detects | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa | 0.440 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropatholo [PMID:40362234] | Unknown | International journal of molec | 2025 | 0 |
| Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory [PMID:35989519] | Sawamura M, Onoe H, Tsukada H | Mov Disord | 2022 | 0 |
| Movement of prion-like α-synuclein along the gut-brain axis in Parkinson's disea [PMID:34043864] | Unknown | The European journal of neuros | 2021 | 0 |
| Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-in [PMID:31628991] | Mezias C, Rey N, Brundin P | Neurobiol Dis | 2020 | 0 |
| Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Mo [PMID:31255487] | ["Kim S", "Kwon S", "Kam T", "Panicker N | Neuron | 2019 | 0 |
| Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal inju [PMID:25853980] | Ulusoy A, Musgrove RE, Rusconi R | Acta Neuropathol Commun | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Vagus Nerve in their description or question text
No additional research found