concept

CENTRAL NERVOUS SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CENTRAL NERVOUS SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

365Connections

0Hypotheses

0Analyses

11Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CENTRAL NERVOUS SYSTEM
Key Genes/Proteins	ACTB, AIF1, ALZHEIMER, amyotrophic lateral sclerosis, ANXIETY, APOE
Related Diseases	aging, Alzheimer'S Disease

Pathway Diagram

graph TD
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    CENTRAL_NERVOUS_SYSTEM -->|"modulates"| Glioblastoma_Multiforme["Glioblastoma Multiforme"]
    CENTRAL_NERVOUS_SYSTEM -->|"expressed in"| Autophagy["Autophagy"]
    GPR37["GPR37"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    BI_hTFR1["BI-hTFR1"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    AQP4["AQP4"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    PIEZO1["PIEZO1"] -->|"involved_in"| CENTRAL_NERVOUS_SYSTEM
    Gut_Microbiota["Gut Microbiota"] -->|"modulates"| CENTRAL_NERVOUS_SYSTEM
    Gut_Brain_Axis["Gut-Brain Axis"] -->|"mediates"| CENTRAL_NERVOUS_SYSTEM
    Microglia["Microglia"] -->|"expressed in"| CENTRAL_NERVOUS_SYSTEM
    Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"] -->|"interacts"| CENTRAL_NERVOUS_SYSTEM

Outgoing (11)

Target	Relation	Type	Str
Hepatocellular Carcinoma	modulates	disease	0.95
Neuromyelitis Optica Spectrum Disorder	involved_in	disease	0.90
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease	involved_in	disease	0.90
Glioblastoma Multiforme	modulates	disease	0.85
Limited Neuroregeneration	associated_with	phenotype	0.85
Self-Repair Potential	associated_with	phenotype	0.85
limited self-repair potential	associated_with	phenotype	0.85
Autophagy	expressed_in	process	0.80
Cellular Senescence	expressed_in	process	0.80
Glioblastoma Multiforme	regulates	disease	0.80
Neuroregeneration	associated_with	process	0.75

Incoming (354)

Source	Relation	Type	Str
Bi-Htfr1	mediates	drug	0.98
Bi-Htfr1	targets	drug	0.96
CRISPR	targets	process	0.95
AQP4	expressed_in	protein	0.95
PIEZO1	involved_in	gene	0.95
SHH	expressed_in	protein	0.95
AQUAPORINS	expressed_in	protein	0.95
AAV-PHP.eB	targets	drug	0.95
Gut Microbiota	associated_with	process	0.95
Cns Extracellular Matrix	expressed_in	biomarker	0.95
BI-hTFR1	mediates	drug	0.95
Viral Vector Gene Therapy	targets	drug	0.95
Gut-Brain Axis	mediates	pathway	0.95
Multiple Sclerosis	associated_with	disease	0.95
Aav-Php.Eb	targets	compound	0.95
Microbiota-Gut-Brain Axis	interacts_with	pathway	0.95
Microglia	expressed_in	cell_type	0.95
HCN	expressed_in	protein	0.95
TREM2	expressed_in	protein	0.92
AAV-PHP.eB	involved_in	drug	0.92
TFRC	associated_with	protein	0.92
AQP1	expressed_in	gene	0.90
AAVT42	targets	drug	0.90
AQP5	expressed_in	gene	0.90
CNS Extracellular Matrix Components	expressed_in	protein	0.90
Tissue-Sensing T Cells	targets	cell_type	0.90
MICROBIOTA	communicates_with	cell_type	0.90
canonical SHH pathway	involved_in	pathway	0.90
gut	interacts_with	brain_region	0.90
sleep	associated_with	process	0.90
Piezo1	associated_with	gene	0.90
AQP9	expressed_in	gene	0.90
AQP3	expressed_in	gene	0.90
Oligonucleotide Transport Vehicle	involved_in	drug	0.88
FUS	expressed_in	protein	0.85
Gut-Brain Axis	modulates	pathway	0.85
non-canonical SHH pathway	involved_in	pathway	0.85
Myeloid Cells	involved_in	cell_type	0.85
TAU	expressed_in	protein	0.85
HCN1	expressed_in	gene	0.85
Crispr-Cas9 Gene Therapy	involved_in	drug	0.85
Gut Microbiota	interacts_with	cell_type	0.85
Alpha-Synuclein Progression	involved_in	process	0.85
VNAR Antibodies	targets	drug	0.85
Protein Filamentous Assembly	expressed_in	process	0.85
Autophagy	involved_in	process	0.85
FTLD-TDP Type C	expressed_in	disease	0.85
Neuroinflammation	expressed_in	process	0.85
Vagus Nerve Pathway	mediates	pathway	0.85
Nanoparticles	associated_with	compound	0.82

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CENTRAL NERVOUS SYSTEM in their description or question text

No additional research found